Carcinoma, Hepatocellular
Conditions
Keywords
Carcinoma, hepatocellular, Portal vein, Proteomics
Brief summary
This is a pilot study to evaluate the difference between the protein expression between hepatocellular carcinoma and tumor with vessel invasion in Asian patients with hepatocellular carcinoma.
Interventions
PROCEDUREOperation
Operation for clinically evaluated resectable hepatocelluar carcinoma. Compare the different expression of protein between tumor, non-tumor and tumor with vascular invasion part.
Sponsors
Far Eastern Memorial Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Arm A: Hepatocellular carcinoma with vessel invasion: * hepatocellular carcionoma, pathologic diagnosed. * image documented vessel invasion, including portal vein thrombosis * eligible for surgical intervension. Arm B: hepatocellular carcinoma without vessel invasion: * hepatocellular carcinoma, pathologic diagnosed or clinical diagnosed according to EASL criteria. * no vessel invasion on image. Arm C: Healthy hepatitis carrier: * patients age \>18 years old with hepatitis B or C * normal liver function.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recurrence | one year | Evidence of clinically definite vascular invasion of hepatocellular carcinoma. Confirmed by operation. Compare the proteomic expression of tumor, non-tumor ans tumor tissue in vascular part. |
Countries
Taiwan
Outcome results
None listed