Substituting Mushrooms for Meat to Control Body Weight

Substituting Mushrooms for Meat: A Controlled Clinical Trial to Control Body Weight

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01177085

Enrollment

100

Registered

2010-08-06

Start date

2009-05-31

Completion date

2010-12-31

Last updated

2018-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

obesity, weight, weight-loss, mushroom, oxidative, stress, immune, function, inflammation

Brief summary

This is a one-year clinical trial to assess weight-loss, weight-maintenance, and biochemical parameters following a weight-control diet using either standard food guide pyramid alone, or standard food guide pyramid with substitution of mushrooms for meat.

Detailed description

This intervention study has a primary aim to assess omnivorous adult males and females' ability to control their weight over a period of 1 year. The control group will be required to use 90% lean ground beef a few times per week for one year while maintaining their personalized diet plans. The experimental group will have to follow their personalized diets as well, but will be required to substitute mushrooms for meat at least three times per week. Biochemical measures will also be assessed in response to the diet and weight loss.

Interventions

BEHAVIORALWeight-loss and weight-maintenance diets

Participants will be given a personalized diet plan, with or without use of mushrooms as part of the diet, at a calorie level sufficiently restricted to result in a 20 lb weight loss over a period of 6 months, followed by a weight maintenance diet for a further 6 months.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Male, female, \>=18 years old * Omnivorous * BMI 25-40 * Seeking weight-loss

Exclusion criteria

* \<18 years old * Vegetarians * Dislike mushroom * Chronic disease * HIV+ * Rheumatoid arthritis * Pregnant or nursing child * Must not self-report allergies to mushrooms

Design outcomes

Primary

Measure	Time frame
Weight-control efficacy	1 year
Weight-loss efficacy	6 months

Secondary

Measure	Time frame
Effect of mushroom-substituted meals on biomarkers for oxidative stress, immune function and inflammation	6 months

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026