Type 2 Diabetes Mellitus
Conditions
Brief summary
The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have T2DM. This project is designed to 1) determine the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether improvement in EPC number and function translates to improved endothelial function, increased capillarization, and improved glucose metabolism in T2DM.
Interventions
OTHERAerobic Exercise Training
6 months of aerobic exercise training, 3 days per week
Sponsors
University of Maryland, Baltimore
Baltimore VA Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 50-80 * Non-smoker * If woman, postmenopausal \>1 year
Exclusion criteria
* History of heart disease or stroke * Cancer * Poorly controlled hypertension or dyslipidemia * Kidney or Liver diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endothelial progenitor cell number | Baseline |
| Skeletal muscle capillarization | Baseline |
Secondary
| Measure | Time frame |
|---|---|
| Cardiorespiratory Fitness | Baseline |
Countries
United States
Outcome results
None listed