Critical Illness, Hyperglycemia
Conditions
Keywords
Critical illness, Hyperglycemia, Catheters, Indwelling, Intensive care unit
Brief summary
The technique of blood samples extraction from the radial artery through an arterial catheter with a 3-way stopcock and automated washing with valve of fast flow is better than the one carried out through a fixed reusable arterial blood sample syringe and its manual washing because it shows a minor incidence of the complications originated from technical manipulation as infection, pseudo-aneurysm, ischemia or thrombosis of radial artery or obstruction of the catheter. The purpose of this study is to evaluate the efficacy, in terms of adverse effects, of blood samples obtention using an arterial catheter with needless connector closed system or an arterial catheter with an arterial blood sample syringe. Also a second purpose is to compare once a day (at the same time) the values of glycose blood levels between bedside glucometer determination of arterial catheter extraction and capillar puncture, and lab determination of glycose from venous puncture, in order to determinate fluctuation in glycose levels due to peripherical hypoperfusion or to vasoactive drugs received by these in-intensive care unit patients.
Interventions
PROCEDUREManual and automated washing of the peripherical lines
The extractions of the blood for the analysis of the glycaemia will be made puncturing the needless connector inserted in the distal 3-way stopcock key once an hour during 48 hours. Obtain 2cc of blood using the arterial blood sampling syringe connected to the proximal key. This volume of rejection is reserved in the syringe itself. In accordance with the current protocol of disinfection, the needless connector inserted on the distal key will be disinfected. With a disposable sterile syringe the needless connector is punctured and a minimum blood amount is obtained for the determination of the glycaemia. Once the sample has been obtained, the rejection volume reserved is returned to the bloodstream. This arterial blood sampling syringe is cleaned aspirating serum manually in order to wash the line. Additional line washing is made through the fast flow valve of the system BD DTXPlus ™.
PROCEDUREAutomated washing of the peripherical lines
The extractions of the blood for the analysis of the glycaemia will be made puncturing the needless connector inserted in the distal 3-way stopcock key once an hour during 48 hours. In accordance with the current protocol of disinfection, the two needless connectors inserted on the two 3-way stopcock keys will be disinfected. With a disposable sterile syringe the needless connector on proximal 3-way stopcock is punctured and 2cc of blood are aspirated. This volume of rejection is reserved in the syringe itself and it is not disconnected. With a second disposable sterile syringe the needless connector on distal 3-way stopcock key is punctured and a minimum blood amount is obtained for the determination of the glycaemia. Once the sample has been obtained, the rejection volume reserved in the disposable syringe connected to the proximal 3-way stopcock is returned to the bloodstream. Line washing will be made through the fast flow valve of the system BD DTXPlus ™.
Sponsors
Consorci Hospitalari de Vic
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Admission in intensive care unit * Insertion of a radial artery catheter for the invasive monitoring of haemodynamic pressure for a maximum of 5 days * Need of insulin therapy by an intravenous continuous perfusion
Exclusion criteria
* Patients who do not accept to participate (or their relatives do not accept) * Patients with a medical limitation of effort therapy * Patients with FloTrac sensor from Edwards Lifesciences which does not allow to add a supplementary 3-way stopcock
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bacteremia episode originated from arterial catheter | At catheter's withdrawal (at seventh day of insertion or at any moment for any clinical reason) | Catheter-related bloodstream infection as defined in Appendix A of Guidelines for the Prevention of Intravascular Catheter-Related Infections. Centers for disease control and prevention (CDC) 2002 August 9: 51(RR10); 27. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Catheter colonization | At catheter's withdrawal (at seventh day of insertion or at any moment for any clinical reason) | Localized catheter colonization as defined in Appendix A of Guidelines for the Prevention of Intravascular Catheter-Related Infections. Centers for disease control and prevention (CDC) 2002 August 9: 51(RR10); 27. |
| Radial artery pseudo-aneurysm | Between 48 and 96 hours after catheter's withdrawal | Diagnosed by the means of Doppler ultrasonography |
| Local infection at cutaneous point of arterial catheter insertion | At catheter's withdrawal (at seventh day of insertion or at any moment for any clinical reason) | Exit site infection as defined in Appendix A of Guidelines for the Prevention of Intravascular Catheter-Related Infections. Centers for disease control and prevention (CDC) 2002 August 9: 51(RR10); 27. |
| Arterial catheter obstruction | From the date of arterial catheter insertion to withdrawal at seventh day or at any moment for any clinical reason | Blood sample obtention from arterial catheter is unavailable. |
| Glycose blood levels | During the two days of catheter manipulation | — |
| Ischemia or thrombosis of radial artery | Between 48 and 96 hours after catheter's withdrawal | Diagnosed by the means of Doppler ultrasonography |
Countries
Spain
Contacts
Primary ContactPere Roura-Poch, MD
Outcome results
None listed