The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01175746

Enrollment

Registered

2010-08-05

Start date

2010-08-31

Completion date

2011-12-31

Last updated

2013-06-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Subjects

Keywords

healthy adult patients, ASA class I, hypotensive anesthesia

Brief summary

Since nicardipine is known to protect kidney function, nicardipine infusion will result in better renal parameters measured in this study.

Interventions

DRUGNicardipine

DRUGremifentanil

0.1-0.5 ugkg/min during hypotensive anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy adult patients undergoing hypotensive anesthesia

Exclusion criteria

* patients with any co-morbidity

Design outcomes

Primary

Measure	Time frame	Description
Creatinine Clearance	2hr after the start of hypotensive anesthesia	Hypotensive anesthesia means that we maintain the mean blood pressure between 55 & 65 mmHg during surgery to decrease the blood loss. The specific time point is exactly 2hr after we star to lower the blood pressure.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026