Heart Valve Diseases
Conditions
Keywords
rheumatic heart disease, degenerated heart valve disease, heart valve prolapse
Brief summary
Remote ischaemic preconditioning has shown its cardiac protective effect during heart surgery including coronary artery bypass graft surgery, congenital heart disease and aneurysm. However, no data was reported on heart valve disease surgery. Rheumatic heart disease is one of the major heart diseases requiring surgery in China. Thus, the investigators chose heart valve disease as a focus to see whether remote ischaemic preconditioning also has cardiac protective effect during heart valve surgery.
Interventions
PROCEDUREremote ischaemic preconditioning
Remote ischaemic preconditioning consisted of three 5-min cycles of right upper arm ischaemia, which was induced by an automated cuff -inflator placed on the right upper arm and inflated to 200 mm Hg, with an intervening 5 min of reperfusion during which the cuff was deflated. There was a 5- to 10-min interval between completion of the remote ischaemic preconditioning protocol and initiation of bypass.Control patients had a deflated cuff placed on the right upper arm for 30 min.
Sponsors
Guangzhou First People's Hospital
Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* All heart valve diseases needing heart valve surgery.
Exclusion criteria
* All four limbs existed ischemic condition
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| plasma troponin I level | with 7 days after surgery | The investigators will measure the plasma troponin I level in several time points before and after surgery in each patient. |
Secondary
| Measure | Time frame |
|---|---|
| serum creatinine | within 7 days after surgery |
Countries
China
Outcome results
None listed