Healthy Subjects
Conditions
Keywords
Liposuction, exercise, metabolism, adiposity
Brief summary
Liposuction is the most popular aesthetic surgery in Brasil and worldwide. Evidence showing that adipose tissue is a metabolically active tissue led to the suggestion that liposuction could be a viable method for the improvement of metabolic profile through the immediate loss of adipose tissue. Studies about the effects of liposuction on metabolic profile are conflicting. A few studies report the improvement of insulin sensitivity, inflammatory markers and lipid profile, others observe no changes and a few report the worsening of metabolic profile. In addition, animal studies show a compensatory growth of intact adipose tissue in response to lipectomy. Physical exercise improves insulin sensitivity, lipid profile, inflammatory balance, adipose tissue distribution and increases or preserves free fat mass. Therefore, liposuction and physical exercise seem to act on similar tissues of the body. To the investigators knowledge, there are no studies about the associated effects of liposuction and exercise in humans. However, one can suggest that exercise training associated with liposuction could: \[1\] attenuate or block the possible fat recovery or compensatory growth; \[2\] block or reverse the possible harmful effects of liposuction; or \[3\] exert an additive or synergistic effect to the possible beneficial effects induced by liposuction on metabolic and hormonal profile and inflammatory balance.
Interventions
PROCEDUREexercise
combined resistance and aerobic training
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 36 Years
Healthy volunteers
Yes
Inclusion criteria
* 20 to 35-year old healthy subjects with a BMI of 22 to 28 Kg/m2; * Non-smokers; * Present stable body weight for 6 months (without variations exceeding 4 kg); * Be in use contraceptive pill for at least 6 months;
Exclusion criteria
* Health problems that impede surgery or exercise training; * Be in chronic use of antibiotics or antiinflammatory medication.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Body composition | 2 months post-intervention | Body composition will be assessed by hydrostatic weighing in order to measure fat and lean mass and by computer tomography, in order to measure abdominal total, subcutaneous and visceral fat areas and femoral and pelvic subcutaneous fat areas. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulin Sensitivity | 2 months post-intervention | Insulin sensitivity will be assessed by an oral glucose tolerance test |
| Total cholesterol, LDL-c, HDL-c, VLDL-c and triacylglycerol plasma levels | 2 months post-intervention | — |
| Cytokine plasma levels - IL-6, TNF-alpha, IL-10, leptin and adiponectin levels | 2 months post-intervention | — |
Countries
Brazil
Outcome results
None listed