The Analgesic Effect of Intrathecal Hydromorphone Injection on Spinal Anesthesia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01172782

Enrollment

Registered

2010-07-30

Start date

2009-07-31

Completion date

2010-07-31

Last updated

2011-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain Measurement, Visual Analog Pain Scale

Brief summary

The purpose of this study is to evaluate the adequate dose of intrathecal hydromorphone injection for postoperative pain relief after knee arthroscopic surgery.

Detailed description

Sixty patients who were undergoing unilateral knee arthroscopy randomly received unilateral spinal anesthesia with 0.5% hyperbaric bupivacaine 6 mg combined with normal saline 0.05 mL or hydromorphone 2.5, 5 or, 10 μg/0.05 mL. The verbal numerical rating scale (VNRS) pain scores were measured at 30 minutes and 2, 4, 6, 12 and 24 hours postoperatively, and the side effects of hydromorphone were recorded.

Interventions

DRUGHydromorphone

2.5, 5, 10 ug of hydromorphone, intrathecal injection, single injection. duration of intrathecal injection are not fully studied.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 72 Years

Healthy volunteers

Yes

Inclusion criteria

* ASA class I-II (age range: 18-72 years) * Informed consent obtained patients

Exclusion criteria

* The

Design outcomes

Primary

Measure	Time frame
Visual Analgesic Numberic Score	during postoperative recovery period.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026