Diabetes Mellitus, Obstructive Sleep Apnea
Conditions
Keywords
obstructive sleep apnea, prevalence, diabetes mellitus, Chinese
Brief summary
OSA is prevalent among patients with type II DM
Detailed description
Obstructive sleep apnea (OSA) has been reported to be common (prevalence ranged from 23-86%) in previous studies involving Caucasian diabetic patients. The investigators aim at finding out the prevalence of OSA in Chinese diabetic patients and identify the clinical predictors associated with OSA. Recruited subjects will undergo overnight polysomnography, anthropometric measurements, blood tests including glycosylated hemoglobin, renal function, glucose level, blood pressure measurement both during the clinic visit and after admission for in-laboratory sleep study.
Interventions
None listed
Sponsors
The University of Hong Kong
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients, age 18 - 75, with type 2 diabetes mellitus, including those on diet, on oral-hypoglycaemic agents or on insulin * Patients who are able to give written consent to undergo polysomnography
Exclusion criteria
* Patients who are unable or unwilling to give written consent to participate in the study * Patients with unstable medical illness or poor functional performance * Patients with recent myocardial infarction or hospital admission for congestive heart failure or cardiac arrhythmia in the past three months * Patients on renal replacement therapy for diabetic nephropathy or chronic renal failure, or plan to start renal replacement therapy in the coming six months * Patients suffered from recent stroke in the past six months or previous history of stroke with significant focal neurological deficit * Patients with type I diabetes * Pregnant lady or lactating women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| presence of OSA | measured at a single time point during the recruitment period(2007-08), by polysomnography | The diagnosis of OSA will be confirmed with polysomnography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| severity of OSA | measured at a single time point during the recruitment period(2007-08), by polysomnography | The severity of OSA will be assessed in terms of apnea hypopnea index, minimal oxygen saturation, duration of desaturation, arousal index during polysomnography |
| glycemic control | measured at a single time point, when the subjects were admitted for polysomnography (during 2007-08) | by measuring glycosylated hemoglobin, blood glucose level |
Countries
Hong Kong
Outcome results
None listed