Repetitive Transcranial Stimulation (rTMS) for Resistant Depression in Adolescents

The Addition of rTMS to the Therapy of Adolescents That Suffer From Treatment Resistant Depression: An Open Label Study

Status

UNKNOWN

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01170520

Enrollment

Registered

2010-07-27

Start date

2010-08-31

Completion date

Unknown

Last updated

2012-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adolescent Depression

Keywords

adolescent resistant depression, repetitive transcranial magnetic stimulation, treatment of resistant adolescent depression

Brief summary

The investigators hypothesis that repetitive transcranial Stimulation (rTMS) is a safe and effective add-on therapy for resistent depression in adolescent patients. A group of adolescents suffering from non psychotic major depression that was resistant to at least 2 drug trials and a trail of psychotherapy will be recruited. After an informed consent procedure for both parents and patients, patients will go through a clinical and cognitive evaluation. They will receive a protocol of 4 weeks (20 work days) of rTMS using the figure of 8 magstim coil at 100% threshold, 42 trains of 4 seconds each, intertrain interval of 30 sec to the LDPC, 1680 pulses per day. Then they will be reevaluated.

Interventions

DEVICErepetitive transcranial Stimulation

rTMS using the figure of 8 magstim for 4 weeks or 20 work days, using 100% threshold to the LDPFC 42 trains per day 4 sec pretrain inter train interval of 30 sec.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

15 Years to 18 Years

Healthy volunteers

Inclusion criteria

* Age 15-18 years old * Right hand dominant * Suffering from major depression * CDRS \> 60 * At least 3 months of current depressive episode * Failed 2 drug trials (or 3 drug trials if trial terminated prematurely due to side effects) and at least 1 course of psychotherapy * No contraindication for rtms (safety questionnaire) * No change in pharmacotherapy in the last month

Exclusion criteria

* Schizophrenia or psychotic symptoms * Hypertension * Epilepsy * History of major head trauma * Metal implements in the head * History of neurosurgery * History of severe head migraine * History of hearing loss or sp cochlear transplantation * Pregnancy * Current drug abuse * Unstable medical condition * History of manic episode * Current treatment with lithium or tricyclic or tetracyclic antidepressants

Design outcomes

Primary

Measure	Time frame
Child Depression Rating Scale (CDRS) comparison before after therapy	4 weeks

Countries

Israel

Contacts

Primary ContactYuval Bloch, MD

yuvalbl@clalit.org.il; aviva100@bezeqint.net972-506264628

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026