Coronary Disease
Conditions
Keywords
Coronary disease, Coronary artery bypass, Cardiac surgery, Computed tomography, Coronary angiography
Brief summary
Recent advances in technology have resulted in the development of scanners that can n image the heart arteries within 10 to 20 minutes but without the need for admission to hospital or insertion of catheters. This means that coronary heart disease may be more readily identified (or ruled out) and allow better diagnosis and treatment of patients with symptoms suggesting coronary heart disease. Here, we propose to assess the latest and most powerful scanners to see if it can accurately diagnose the extent of coronary artery disease and facilitate the planning of heart surgery.
Interventions
RADIATIONComputed tomography scan
Computed tomography will be performed using a 320 multidetector computed tomography scanner and may include coronary calcium score, coronary angiography and myocardial perfusion scanning.
Sponsors
University of Edinburgh
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients who have undergone conventional coronary angiography and have been referred for coronary artery bypass surgery or valve replacement
Exclusion criteria
* age less than 18 * pregnancy or breast feeding * inability to undergo computed tomography scanning * inability to give informed consent * severe renal failure (serum creatinine \>250umol/l or estimated glomerular filtration rate \<15ml/min) * known allergy to iodinated contrast
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coronary artery stenosis defined qualitatively by trained observers and quantitatively by computer software | 1 month |
Secondary
| Measure | Time frame |
|---|---|
| Myocardial perfusion defects defined qualitatively by trained observers and quantitatively by computer software | 1 month |
Countries
United Kingdom
Outcome results
None listed