Hyperbilirubinemia, Neonatal, Jaundice, Neonatal
Conditions
Keywords
Hyperbilirubinemia, Neonatal, Serum bilirubin, Transcutaneous bilirubin, Skin color
Brief summary
Prospective comparison of measurement of bilirubin in jaundiced newborns by a transcutaneous device (bilirubinometer) and laboratory analysis of blood samples. We hypothesise that correlation of the two measurements depend on bilirubin level, gestational age as well as postnatal age.
Detailed description
Whenever a blood sample is drawn for measurement of bilirubin in a newborn, a transcutaneous measurement of skin yellow color will be made. Such measurements will also be included in all infants when a CRP-test (blood sample for C-reactive protein) has been ordered, as well as in connection with the routine blood sampling for metabolic screening. Only infants where parents have given written consent for their infant will be included in the study.
Interventions
PROCEDUREMeasurement of bilirubin in blood and skin color
Blood sampling and analysis, measurement of skin color by transcutaneous bilirubinometry
Sponsors
Norwegian University of Science and Technology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 28 Days
Healthy volunteers
Yes
Inclusion criteria
* Newborn infant admitted to normal newborn nursery
Exclusion criteria
* Informed consent not obtained
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of transcutaneous bilirubin (skin color, TcB) and bilirubin measured in a blood sample (TsB) | 12 months | To have statistical strength for comparison of the two tests between 1500 and 2000 patients are needed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Differences in TcB measured at the forehead or at the sternum | 12 months | To have statistical strength for comparison of the two tests between 1500 and 2000 patients are needed |
Countries
Norway
Outcome results
None listed