Respiratory Virus Infection
Conditions
Keywords
upper respiratory tract infection, lower respiratory tract infection
Brief summary
This study aims to prospectively estimate the incidence of Respiratory virus (RV) infections in children with symptoms of an upper respiratory tract infection (URTI) or lower respiratory tract infection (LRTI) at St. Jude Children's Research Hospital (SJCRH) using the FilmArrayTM System, a novel highly sensitive and rapid assay for RV detection. An aliquot from the leftover sample remaining after clinical diagnostic testing will be used for FilmArrayTM analysis. Patients will be accrued on the study over a one year period.
Detailed description
The Primary Objective of the study is: * Prospectively estimate the incidence of Respiratory virus (RV) infections in children with symptoms of an upper respiratory tract infection (URTI) or lower respiratory tract infection (LRTI) at St. Jude Children's Research Hospital(SJCRH). The Secondary Objectives of the study are: * Study the association between RV infections and clinical variables. * Prospectively estimate the duration of RV infections in symptomatic children at SJCRH. * Compare the sensitivity and specificity of the current molecular method of analysis of respiratory viruses with the FilmArrayTM method.
Interventions
None listed
Sponsors
St. Jude Children's Research Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* Birth to less than or equal to 18 years. * Patients with an URTI or LRTI undergoing collection of respiratory secretions at SJCRH, by nasopharyngeal wash, nasopharyngeal swab, tracheal aspirate or bronchoalveolar lavage as ordered by the treating physician.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| This study measures the incidence of Respiratory virus (RV) infections in children with symptoms of an upper respiratory tract infection (URTI) or lower respiratory tract infection (LRTI) using the FilmArray System | 1 year | This study uses FilmArrayTM System, a novel highly sensitive and rapid assay for respiratory virus infection. An aliquot from the leftover sample remaining after clinical diagnostic testing will be used for FilmArrayTM analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| This study analyses respiratory viruses using Filmarray TM method | 1 year | — |
| Time of first detection of the virus as related to day of transplant, Time of first detection of the virus as related to day of chemotherapy and duration of viral shedding from the time of first detection will all be measured. | 1 year | Different variables will be collected to find the association between Respiratory virus and clinical variables |
| This study prospectively estimates and measures the duration of Respiratory Virus infections in symptomatic children by studying the epidemiology and natural history of infections with these viruses . | 1 year | These viruses have been known to cause interstitial lung disease, will help clarify the etiology of idiopathic pneumonia post chemotherapy . |
Countries
United States
Outcome results
None listed