Effect of Electrostimulation in Chronic Obstructive Pulmonary Disease (COPD)

Effect of Electromyostimulation in Severe Chronic Obstructive Pulmonary Disease

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01167283

Acronym

ExaEMS2005

Enrollment

Registered

2010-07-22

Start date

2006-07-31

Completion date

2010-04-30

Last updated

2010-08-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

COPD

Brief summary

This study was designed to test the following hypothesis: To investigate whether COPD muscles can respond to stimuli in terms of changes in fiber-type distribution.

Detailed description

Background: Muscle dysfunction is a major problem in chronic obstructive pulmonary disease (COPD). It is characterized by muscle fiber-type redistribution and oxidative stress. Classical training does not improve these features. Objectives: To investigate whether electrostimulation program following exacerbation can modify muscle structure and function in COPD patients. Method: We propose to conduct a controlled and randomized clinical trial comparing the efficacy of muscle electrostimulation training of the lower limbs to sham training in 15 patients with COPD. Patients are included in either 6 weeks of electrostimulation training (active treatment group) or 6 weeks of sham electrostimulation. Primary outcomes were changes in muscle structure, muscle oxidative stress and their relationship with quadriceps force and exercise tolerance.

Interventions

DEVICEElectrostimulation

Electrostimulation: 35 Hz, 0.4 ms, 1 h; 5 times/week

DEVICESham stimulation

Sham stimulation: 1 h; 5 times/week

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

50 Years to 80 Years

Healthy volunteers

Inclusion criteria

* COPD patients during or after exacerbation

Exclusion criteria

* Comorbidities that could limit exercise training * Obesity (body mass index \[BMI\] \> 30 kg/m²) * Neuromuscular disease * Pacemaker implantation

Design outcomes

Primary

Measure	Time frame	Description
Fiber-type distribution	6 to 8 weeks	Typology was evaluated by immunohistochemistry

Secondary

Measure	Time frame
Change in the strength of the quadriceps over the 6-week electrostimulation program	6 to 8 weeks

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026