CIRRHOSIS
Conditions
Keywords
Cirrhosis, Malnutrition, Enteral nutrition
Brief summary
The benefits of short-term naso-gastric feeding in patients with advanced cirrhosis remain uncertain. This was a randomised study comparing naso-gastric feeding and oral feeding in Asian patients with cirrhosis who were admitted to hospital for decompensation.
Detailed description
Consecutive patients with decompensated cirrhosis who fitted the inclusion criteria, will be randomised to either naso-gastric or oral feeding. Total feeding will be for 2 weeks only. Following intervention specific nutritional and liver-related parameters will be measured during the 2 weeks and up to 6 weeks later. Comparison between both groups will then be made.
Interventions
DIETARY_SUPPLEMENTOsmolite and B.C.A.A.
Feeding inserted into enteral tubes
DIETARY_SUPPLEMENTNormal oral intake & supplementation if necessary
Enteral nutrition
Sponsors
University of Malaya
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with decompensated cirrhosis of any etiology.
Exclusion criteria
* Advanced hepatic encephalopathy, * Variceal bleeding, * Hepatocellular carcinoma.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement in Child-Pugh score | Up to 6 weeks | Change in the Child-Pugh score, assessing liver damage in cirrhosis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Improvement in nutritional parameters | up to 6 weeks | Improvement in nutritional anthropometry and assessment tool markers after intervention |
Countries
Malaysia
Outcome results
None listed