Food Allergy
Conditions
Keywords
Atopy patch test
Brief summary
Positive reactions in Atopy patch test in children with food allergy-related gastrointestinal symptoms
Detailed description
The prevalence of food allergy seems to be increasing, which might explain the increased demand for reliable evaluation of patients with suspected food-related gastrointestinal symptoms. Little is known about the diagnostic accuracy of atopy patch tests(APT) in the clinical practice. APT seems to have a better specificity than the IgE methods and seems to reflect late-phase clinical reactions.The aims of this study were to evaluate: (i) The prevalence of positive reaction of APTs for food allergy-related gastrointestinal diseases. (ii)Positive reaction of APT compare with skin prick test. (iii)Positive reaction of APT using lyophilized food vs commercially available food extracts. (iv)Side effect or adverse events of APT
Interventions
Atopy patches used with food lyophilized allergen and commercial allergen were placed on back of subjects for 48 hrs then atopy patches were taken off. Subjects should return to evaluate the reaction one day later (72 hr after applying atopy patch test)
Sponsors
Mahidol University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Months to 18 Years
Healthy volunteers
No
Inclusion criteria
* Patients who had history of suspected food allergy-related gastrointestinal symptoms eg. nausea and vomiting, diarrhea, abdominal pain or hematochezia after ingesting some food. * Age 1 month-18 yrs * Elimination diet was done at least 7 days before starting the study * Written informed consent was obtained from the parents of each child enrolled in the study
Exclusion criteria
* Who have dermographism * Who have chronic disease eg. autoimmune disease, immune deficiency, cancer or allergic disease * Pregnant women * Who have severe eczema * Who receive antihistamine, topical steroid and systemic steroid \> 20 mg/day withiin 7 days prior study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of positive reaction in APT in children with food allergy-related gastrointestinal symptoms | 3 days | To evaluate (i) The prevalence of positive reaction of APTs for food allergy-related gastrointestinal diseases. (ii)Positive reaction of APT compare with skin prick test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparisons atopy patch test reaction between lyophilized allergen and commercial allergen | 3 days | To evaluate (iii)Positive reaction of APT using lyophilized food vs commercially available food extracts. (iv)Side effect or adverse events of APT |
Countries
Thailand
Outcome results
None listed