Hookworm Infections, Malaria, Falciparum, Schistosoma Haematobium
Conditions
Keywords
iron absorption, iron utilization, malaria, helminth, Ivory Coast, Acute symptomatic uncomplicated falciparum malaria, Asymptomatic falciparum malaria, Moderate to heavy hookworm infection, Heavy Schistosoma haematobium infection
Brief summary
The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.
Detailed description
The aim of the study is to determine how iron metabolism in subjects with infectious diseases (malaria, hookworm or S. haematobium) differs while infected and after treatment, i.e. the same individuals will be restudied while free of infection.
Interventions
DIETARY_SUPPLEMENTFe-57 orally, Fe-58 intravenously
Subjects will receive a test drink containing 3 mg Fe-57 in the form of labelled FeSO4 followed by 1 ml of an aqueous solution containing 50 μg Fe-58 as iron citrate.
Sponsors
Swiss Federal Institute of Technology
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
12 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* Children aged 12 to 16 years * Body weight \> 30 kg * no chronic medical illnesses * no intake of vitamin/mineral supplements 2 weeks before the study and until the last blood drawing * For each of the 4 arms the respective disease needs to be present (symptomatic malaria, asymptomatic malaria, hookworm infection, S. haematobium infection) without any other concurrent infection
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Isotope absorption into blood stream | Day 15 |
Secondary
| Measure | Time frame |
|---|---|
| Isotope incorporation into erythrocytes | Day 15 |
| Biochemical parameters of iron status and infection | Day 1 |
Countries
Côte d’Ivoire
Outcome results
None listed