A Proposal to Test the Efficacy and Tolerability of Bortezomib in Pulmonary Chronic GVHD

A Phase 2 Proposal to Test the Efficacy and Tolerability of Bortezomib in Pulmonary Chronic GVHD

Status

Terminated

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01163786

Enrollment

Registered

2010-07-16

Start date

2010-10-07

Completion date

2015-09-09

Last updated

2020-04-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchiolitis Obliterans

Keywords

Bortezomib GVHD Bronchiolitis Obliterans

Brief summary

Approximately 10,000 allogeneic hematopoietic stem cell transplants (HSCT) are performed annually in the US for various indications. Bronchiolitis obliterans (BO) is the most common late noninfectious complication following allogeneic hematopoietic stem cell transplant. Prognosis of BO in the allogeneic HSCT setting is dismal and there are no therapies proven to be consistently effective. The exact incidence is not clear but may be as high as 30%2 . Risk factors include new or ongoing chronic graft versus host disease (cGVHD), age, antecedent obstructive airways disease and viral infections1. BO is characterized physiologically by progressive irreversible airflow obstruction and pathologically by luminal occlusion of the distal airways due to progressive scarring3. The pathogenesis is not completely understood but the cytokine transforming growth factor-beta 1 (TGF-b1), important for both tissue repair and fibrosis, is thought to play a pivotal role. Bortezomib, an FDA approved proteasomal inhibitor inhibits TGF-b1 signaling in vitro and protects against lung injury/fibrosis in bleomycin mouse model as well as in a mouse model for skin fibrosis. This is consistent with other data in the literature that proteasomal inhibition can prevent the development of fibrosis. Thus the investigators propose to test the safety, tolerability and efficacy of bortezomib in chronic pulmonary GVHD (BO).

Interventions

DRUGBortezomib

Each patient will receive 2 cycles of Bortezomib. For each cycle Bortezomib wil be given once a week, 1.3mg/m2 for 4 weeks with 2 weeks between each cycle.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Voluntary written informed consent before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care. * Female subject is either post-menopausal or surgically sterilized or willing to use an acceptable method of birth control (i.e., a hormonal contraceptive, intra-uterine device, diaphragm with spermicide, condom with spermicide, or abstinence) for the duration of the study. * Male subject agrees to use an acceptable method for contraception for the duration of the study. * Day \>100 after allogeneic hematopoietic stem cell transplantation * Underlying cancer in remission * Decrease in FEV1 of ≥12% from the pre-transplant baseline (FEV1/FVC ratio \<0.8) * No evidence of acute infection * ANC \>1000 * Platelets \>50,000 * Age 18-70 * ECOG performance Status 0-2.

Exclusion criteria

* Patient has a platelet count of less than 50,000 within 14 days before enrollment. * Patient has an absolute neutrophil count of less 1000 within 14 days before enrollment. * Patient has a calculated or measured creatinine clearance of \< 20 ml/minute within 14 days before enrollment. * Patient has Grade 2 peripheral neuropathy within 14 days before enrollment. * Myocardial infarction within 6 months prior to enrollment or has New York Heart Association (NYHA) Class III or IV heart failure (see section 8.4), uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Prior to study entry, any ECG abnormality at Screening has to be documented by the investigator as not medically relevant. * Patient has hypersensitivity to bortezomib, boron or mannitol. * Female subject is pregnant or breast-feeding. Confirmation that the subject is not pregnant must be established by a negative serum b-human chorionic gonadotropin (b-hCG) pregnancy test result obtained during screening. Pregnancy testing is not required for post-menopausal or surgically sterilized women. * Patient has received other investigational drugs with 14 days before enrollment * Serious medical or psychiatric illness likely to interfere with participation in this clinical study. * Inability of give consent

Design outcomes

Primary

Measure	Time frame	Description
Change in Pulmonary Function as Measured by Forced Expiratory Volume in 1 Second (FEV1) Decline	Mean time to diagnosis (from transplant to p-CGVHD ) of 3.36 years (+/- 1.88 years) and up to 18 weeks after baseline	FEV1 will be measured by spirometry assessments at baseline (pre-transplant baseline - prior to pulmonary chronic graft-versus-host disease (p-CGVHD)) during treatment (10 weeks) and at follow up visit 9 (at 12 weeks) and at follow up visit 10 (at 18 weeks) with patients having spirometry tested up to 6 times from screening to the end of the study. FEV1 is reported as slopes computed by dividing difference in FEV1 by time in months.

Secondary

Measure	Time frame	Description
Exercise Tolerance- 6 Minute Walk	Up to 18 weeks from baseline	Patients will have an exercise tolerance assessment defined as a 6 minute walk completed at cycle 1 (week 1) and cycle 2 (week 5) of treatment and visit 9 (12 weeks) and visit 10 (18 weeks).
Short Form (SF)-36 Health Survey	up to 18 weeks	This is a quality of life questionnaire which yields scores for 8 domains (physical functioning, role-physical, bodily pain, general health, vitality, social functioning, role-emotional and mental health). This questionnaire will be completed by patients on Visit 1 (week 1), Visit 5 (week 5), Visit 8 (week 8), Visit 9 (12 weeks), and Visit 10 (18 weeks). Questionnaires were scored per the scoring rules for the RAND 36-Item Health Survey (version 1.0) A high score defines a more favorable health state. In addition, each item is scored on a 0 to 100 range so that the lowest and highest possible scores are 0 and 100, respectively. Scores represent the percentage of total possible score achieved. Items that are left blank (missing data) are not taken into account when calculating the scale scores. Hence, scale scores represent the average for all items in the scale that the respondent answered.

Countries

United States

Participant flow

Recruitment details

The study opened for accrual on July 20, 2010 with an accrual goal of up to 20 evaluable patients. The first patient being enrolled on the study on October 7th 2010. The study was closed permanently on August 31 2015 before the accrual goal was met with 17 patients being treated on study.

Pre-assignment details

Patients were diagnosed with pulmonary Chronic Graft Verses Host Disease (p-CGVHD) after having undergone allogeneic hematopoietic stem cell transplant (HSCT). Patients were required to be less than 100 days post HSCT, with an absolute decrease of 12% or more in forced expiratory volume in 1 second (FEV1) from pre-transplant baseline.

Participants by arm

Arm	Count
Bortezomib Patients will receive 2 cycles of Bortezomib (given weekly for 4 weeks) for a total of 8 doses of Bortezomib. Each cycle will consist of weekly bortezomib with a 2 week interval between cycles. Bortezomib: Each patient will receive 2 cycles of Bortezomib. For each cycle Bortezomib will be given once a week, 1.3mg/m2 for 4 weeks with 2 weeks between each cycle.	17
Total	17

Withdrawals & dropouts

Period	Reason	FG000
Completed Follow up (Visit 9 and 10)	Other	1
Treatment With Bortezomib	Adverse Event	2
Treatment With Bortezomib	Withdrawal by Subject	1

Baseline characteristics

Characteristic	Bortezomib
Age, Categorical <=18 years	0 Participants
Age, Categorical >=65 years	2 Participants
Age, Categorical Between 18 and 65 years	15 Participants
Disease Acute Leukemia	6 Participants
Disease Chronic Myelogenous Leukemia	3 Participants
Disease Lymophoma	4 Participants
Disease Myeloma	2 Participants
Disease Other	2 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	3 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	14 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants
lumonary Function Testing at time of pulmonary Chronic Graft-verses-host disease (pGVHD) Diagnosis FEV/FVC	61 percentage STANDARD_DEVIATION 14
lumonary Function Testing at time of pulmonary Chronic Graft-verses-host disease (pGVHD) Diagnosis Forced Expiratory Volume in 1 Second (FEV1)	47 percentage STANDARD_DEVIATION 16
lumonary Function Testing at time of pulmonary Chronic Graft-verses-host disease (pGVHD) Diagnosis Forced Vital Capacity (FVC)	60 percentage STANDARD_DEVIATION 15
Plumonary Function Testing (PFT) at time of transplant FEV/FVC	81 percentage STANDARD_DEVIATION 5
Plumonary Function Testing (PFT) at time of transplant Forced Expiratory Volume in 1 Second (FEV1)	90 percentage STANDARD_DEVIATION 17
Plumonary Function Testing (PFT) at time of transplant Forced Vital Capacity (FVC)	89 percentage STANDARD_DEVIATION 18
Race (NIH/OMB) American Indian or Alaska Native	0 Participants
Race (NIH/OMB) Asian	0 Participants
Race (NIH/OMB) Black or African American	1 Participants
Race (NIH/OMB) More than one race	0 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants
Race (NIH/OMB) Unknown or Not Reported	1 Participants
Race (NIH/OMB) White	15 Participants
Region of Enrollment United States	17 participants
Sex: Female, Male Female	4 Participants
Sex: Female, Male Male	13 Participants
Sex Matching of Transplantation Female-female	1 Participants
Sex Matching of Transplantation Female-male	3 Participants
Sex Matching of Transplantation male-female	5 Participants
Sex Matching of Transplantation male-male	8 Participants
Time from transplant to pGVHD diagnosis	3.36 years STANDARD_DEVIATION 1.88
Transplant Type Matched Sibling	12 Participants
Transplant Type Matched unrelated	4 Participants
Transplant Type Mini matched unrelated	1 Participants

Adverse events

Event type	EG000 affected / at risk
deaths Total, all-cause mortality	0 / 17
other Total, other adverse events	17 / 17
serious Total, serious adverse events	3 / 17

Outcome results

Primary

Change in Pulmonary Function as Measured by Forced Expiratory Volume in 1 Second (FEV1) Decline

FEV1 will be measured by spirometry assessments at baseline (pre-transplant baseline - prior to pulmonary chronic graft-versus-host disease (p-CGVHD)) during treatment (10 weeks) and at follow up visit 9 (at 12 weeks) and at follow up visit 10 (at 18 weeks) with patients having spirometry tested up to 6 times from screening to the end of the study. FEV1 is reported as slopes computed by dividing difference in FEV1 by time in months.

Time frame: Mean time to diagnosis (from transplant to p-CGVHD ) of 3.36 years (+/- 1.88 years) and up to 18 weeks after baseline

Arm	Measure	Group	Value (MEDIAN)
Bortezomib	Change in Pulmonary Function as Measured by Forced Expiratory Volume in 1 Second (FEV1) Decline	Prior to diagnosis of p-CGVHD	-1.06 percentage per month
Bortezomib	Change in Pulmonary Function as Measured by Forced Expiratory Volume in 1 Second (FEV1) Decline	During Treatment with Bortezomib	-0.25 percentage per month

Secondary

Exercise Tolerance- 6 Minute Walk

Patients will have an exercise tolerance assessment defined as a 6 minute walk completed at cycle 1 (week 1) and cycle 2 (week 5) of treatment and visit 9 (12 weeks) and visit 10 (18 weeks).

Time frame: Up to 18 weeks from baseline

Population: Data was collected but not analyzed due to the study closing before accrual was met. Below is data on how many patients started 6 minute walk and how many patients stopped before reaching 6 minutes at each time point is shown below.

Arm	Measure	Group	Value (NUMBER)
Bortezomib	Exercise Tolerance- 6 Minute Walk	Cycle 1 (Visit 1): Started 6 Minute walk	13 participants
Bortezomib	Exercise Tolerance- 6 Minute Walk	Cycle 1 (Visit 1): Stopped before 6 minutes	3 participants
Bortezomib	Exercise Tolerance- 6 Minute Walk	Cycle 1(Visit 1):Declined walk	0 participants
Bortezomib	Exercise Tolerance- 6 Minute Walk	Cycle 2 (Visit 5) : Started 6 Minute walk	3 participants
Bortezomib	Exercise Tolerance- 6 Minute Walk	Cycle 2 (Visit 5) : Stopped before 6 minutes	0 participants
Bortezomib	Exercise Tolerance- 6 Minute Walk	Cycle 2(Visit 5):Declined walk	0 participants
Bortezomib	Exercise Tolerance- 6 Minute Walk	Follow up/Visit 9: Started 6 Minute walk	6 participants
Bortezomib	Exercise Tolerance- 6 Minute Walk	Follow up/Visit 9 : Stopped before 6 minutes	1 participants
Bortezomib	Exercise Tolerance- 6 Minute Walk	Follow up/Visit 9: Declined walk	1 participants
Bortezomib	Exercise Tolerance- 6 Minute Walk	Follow up/Visit 10 : Started 6 Minute walk	5 participants
Bortezomib	Exercise Tolerance- 6 Minute Walk	Follow up/Visit 10 : Stopped before 6 minutes	1 participants
Bortezomib	Exercise Tolerance- 6 Minute Walk	Follow up/Visit 10: Declined walk	1 participants

Secondary

Short Form (SF)-36 Health Survey

This is a quality of life questionnaire which yields scores for 8 domains (physical functioning, role-physical, bodily pain, general health, vitality, social functioning, role-emotional and mental health). This questionnaire will be completed by patients on Visit 1 (week 1), Visit 5 (week 5), Visit 8 (week 8), Visit 9 (12 weeks), and Visit 10 (18 weeks). Questionnaires were scored per the scoring rules for the RAND 36-Item Health Survey (version 1.0) A high score defines a more favorable health state. In addition, each item is scored on a 0 to 100 range so that the lowest and highest possible scores are 0 and 100, respectively. Scores represent the percentage of total possible score achieved. Items that are left blank (missing data) are not taken into account when calculating the scale scores. Hence, scale scores represent the average for all items in the scale that the respondent answered.

Time frame: up to 18 weeks

Population: Data was collected but not analyzed. Averages for each patient at each timepoint are shown below. N/a is shown for timepoints where data was not collected.

Arm	Measure	Group	Value (NUMBER)
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Emotional Well-being : Visit 1	88 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Role-physical : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Role-physical : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Role-physical : Visit 8	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Physical Functioning : Visit 1	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Physical Functioning : Visit 5	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Physical Functioning : Visit 8	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Physical Functioning : Visit 9	70 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Physical Functioning : Visit 10	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 Role-physcial : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 Role-physcial : Visit 5	33.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 Role-physcial : Visit 8	66.67 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 Role-physcial : Visit 9	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 Role-physcial : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Role-emotional : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Role-emotional : Visit 5	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Role-emotional : Visit 8	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Role-emotional : Visit 9	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Role-emotional : Visit 10	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Energy/fatigue : Visit 1	40 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Energy/fatigue : Visit 5	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Energy/fatigue : Visit 8	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Energy/fatigue : Visit 9	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Energy/fatigue : Visit 10	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 : Emotional Well-being : Visit 1	52 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 : Emotional Well-being : Visit 5	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 : Emotional Well-being : Visit 8	52 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 : Emotional Well-being : Visit 9	92 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 : Emotional Well-being : Visit 10	92 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Social Functioning : Visit 1	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Social Functioning : Visit 5	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Social Functioning : Visit 8	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Social Functioning : Visit 9	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: Social Functioning : Visit 10	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 Pain : Visit 1	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 Pain : Visit 5	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 Pain : Visit 8	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 Pain : Visit 9	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8 Pain : Visit 10	90 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: General Health : Visit 1	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: General Health : Visit 5	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: General Health : Visit 8	55 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: General Health : Visit 9	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #8: General Health : Visit 10	65 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Physical Functioning : Visit 1	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Physical Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Physical Functioning : Visit 8	70 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Physical Functioning : Visit 9	70 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Physical Functioning : Visit 10	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Role-physical : Visit 9	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Role-physical : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Role-emotional : Visit 1	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Role-emotional : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Role-emotional : Visit 8	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Role-emotional : Visit 9	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Role-emotional : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Energy/fatigue : Visit 1	70 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Energy/fatigue : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Energy/fatigue : Visit 8	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Energy/fatigue : Visit 9	70 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Energy/fatigue : Visit 10	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Emotional Well-being : Visit 1	84 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Emotional Well-being : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Emotional Well-being : Visit 8	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Emotional Well-being : Visit 9	92 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Emotional Well-being : Visit 10	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Social Functioning : Visit 1	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Social Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Social Functioning : Visit 8	62.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Social Functioning : Visit 9	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Social Functioning : Visit 10	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Pain : Visit 1	77.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Pain : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Pain : Visit 8	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Pain : Visit 9	77.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: Pain : Visit 10	67.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: General Health : Visit 1	70 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: General Health : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: General Health : Visit 8	31.25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: General Health : Visit 9	40 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #9: General Health : Visit 10	56.25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Physical Functioning : Visit 1	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Physical Functioning : Visit 5	90 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Physical Functioning : Visit 8	83.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Physical Functioning : Visit 9	85 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Physical Functioning : Visit 10	85 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Role-physical : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Role-physical : Visit 5	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Role-physical : Visit 8	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Role-physical : Visit 9	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Role-physical : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Role-emotional : Visit 1	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Role-emotional : Visit 5	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Role-emotional : Visit 8	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Role-emotional : Visit 9	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Role-emotional : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Energy/fatigue : Visit 1	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Energy/fatigue : Visit 5	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Energy/fatigue : Visit 8	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Energy/fatigue : Visit 9	65 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Energy/fatigue : Visit 10	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Emotional Well-being : Visit 1	88 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Emotional Well-being : Visit 5	84 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Emotional Well-being : Visit 8	84 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Emotional Well-being : Visit 9	92 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10: Emotional Well-being : Visit 10	92 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 : Social Functioning : Visit 1	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 : Social Functioning : Visit 5	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 : Social Functioning : Visit 8	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 : Social Functioning : Visit 9	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 : Social Functioning : Visit 10	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 Pain : Visit 1	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 Pain : Visit 5	77.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 Pain : Visit 8	77.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 Pain : Visit 9	77.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 Pain : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 Visit 1 : General Health : Visit 1	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 Visit 1 : General Health : Visit 5	65 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 Visit 1 : General Health : Visit 8	65 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 Visit 1 : General Health : Visit 9	65 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #10 Visit 1 : General Health : Visit 10	65 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Physical Functioning : Visit 1	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Physical Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Physical Functioning : Visit 8	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Physical Functioning : Visit 9	5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Physical Functioning : Visit 10	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Role-physical : Visit 1	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Role-physical : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Role-physical : Visit 8	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Role-physical : Visit 9	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Role-physical : Visit 10	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Role-emotional : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Role-emotional : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Role-emotional : Visit 8	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Role-emotional : Visit 9	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Role-emotional : Visit 10	66.67 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Energy/fatigue : Visit 1	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Energy/fatigue : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Energy/fatigue : Visit 8	40 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Energy/fatigue : Visit 9	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Energy/fatigue : Visit 10	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Emotional Well-being : Visit 1	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Emotional Well-being : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Emotional Well-being : Visit 8	84 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Emotional Well-being : Visit 9	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Emotional Well-being : Visit 10	68 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Social Functioning : Visit 1	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Social Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Social Functioning : Visit 8	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Social Functioning : Visit 9	37.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Social Functioning : Visit 10	62.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Pain : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Pain : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Pain : Visit 8	22.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Pain : Visit 9	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 Visit 1 : Pain : Visit 10	22.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 General Health : Visit 1	5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 General Health : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 General Health : Visit 8	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 General Health : Visit 9	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #11 General Health : Visit 10	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Physical Functioning : Visit 1	35 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Physical Functioning : Visit 5	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Physical Functioning : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Physical Functioning : Visit 9	40 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Physical Functioning : Visit 10	44.44 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Role-physical : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Role-physical : Visit 5	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Role-physical : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Role-physical : Visit 9	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Role-physical : Visit 10	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Role-emotional : Visit 1	33.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Role-emotional : Visit 5	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Role-emotional : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Role-emotional : Visit 9	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Role-emotional : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Energy/fatigue : Visit 1	40 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Energy/fatigue : Visit 5	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Energy/fatigue : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Energy/fatigue : Visit 9	65 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Energy/fatigue : Visit 10	70 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Emotional Well-being : Visit 1	68 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Emotional Well-being : Visit 5	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Emotional Well-being : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Emotional Well-being : Visit 9	72 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Emotional Well-being : Visit 10	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Social Functioning : Visit 1	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Social Functioning : Visit 5	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Social Functioning : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Social Functioning : Visit 9	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Social Functioning : Visit 10	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Pain : Visit 1	77.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Pain : Visit 5	55 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Pain : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Pain : Visit 9	67.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 Pain : Visit 10	77.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 General Health : Visit 1	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 General Health : Visit 5	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 General Health : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 General Health : Visit 9	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #12 General Health : Visit 10	55 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt#13 Physical Functioning : Visit 1	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt#13 Physical Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt#13 Physical Functioning : Visit 8	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt#13 Physical Functioning : Visit 9	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt#13 Physical Functioning : Visit 10	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Role-physical : Visit 1	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Role-physical : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Role-physical : Visit 8	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Role-physical : Visit 9	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Role-physical : Visit 10	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Role-emotional : Visit 1	33.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Role-emotional : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Role-emotional : Visit 8	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Role-emotional : Visit 9	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Role-emotional : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Energy/fatigue : Visit 1	40 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Energy/fatigue : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Energy/fatigue : Visit 8	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Energy/fatigue : Visit 9	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Energy/fatigue : Visit 10	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Emotional Well-being : Visit 1	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Emotional Well-being : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Emotional Well-being : Visit 8	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Emotional Well-being : Visit 9	64 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Emotional Well-being : Visit 10	72 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Social Functioning : Visit 1	62.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Social Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Social Functioning : Visit 8	62.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Emotional Well-being : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Social Functioning : Visit 9	62.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Social Functioning : Visit 10	62.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Social Functioning : Visit 1	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Social Functioning : Visit 5	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Pain : Visit 1	67.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Social Functioning : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Pain : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Social Functioning : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Pain : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Pain : Visit 8	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Pain : Visit 8	32.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Pain : Visit 9	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Pain : Visit 9	32.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 Pain : Visit 10	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Pain : Visit 10	32.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Role-physical : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 General Health : Visit 1	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 General Health : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 General Health : Visit 8	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 General Health : Visit 9	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #13 General Health : Visit 10	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Physical Functioning : Visit 1	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Physical Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Physical Functioning : Visit 8	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Physical Functioning : Visit 9	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Physical Functioning : Visit 10	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Role-physical : Visit 1	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Role-physical : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Role-physical : Visit 8	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Role-physical : Visit 9	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Role-physical : Visit 10	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Role-emotional : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Role-emotional : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Role-emotional : Visit 8	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Role-emotional : Visit 9	33.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Role-emotional : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Energy/fatigue : Visit 1	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Physical Functioning : Visit 1	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Physical Functioning : Visit 5	55 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Physical Functioning : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Physical Functioning : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Physical Functioning : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Role-physical : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Role-physical : Visit 5	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Role-physical : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Role-physical : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Role-physical : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Role-emotional : Visit 1	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Role-emotional : Visit 5	66.67 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Role-emotional : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Role-emotional : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Role-emotional : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Energy/fatigue : Visit 1	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Energy/fatigue : Visit 5	35 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Energy/fatigue : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Energy/fatigue : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Energy/fatigue : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Emotional Well-being : Visit 1	88 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Emotional Well-being : Visit 5	84 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Emotional Well-being : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Emotional Well-being : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Social Functioning : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Pain : Visit 1	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Pain : Visit 5	55 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Pain : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Pain : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 Pain : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 General Health : Visit 1	65 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 General Health : Visit 5	55 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 General Health : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 General Health : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #01 General Health : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Physical Functioning : Visit 1	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Physical Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Physical Functioning : Visit 8	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Physical Functioning : Visit 9	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Physical Functioning : Visit 10	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Role-physical : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Role-physical : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Role-physical : Visit 8	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Role-physical : Visit 9	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Role-physical : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Role-emotional : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Role-emotional : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Role-emotional : Visit 8	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Role-emotional : Visit 9	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Role-emotional : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Energy/fatigue : Visit 1	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Energy/fatigue : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Energy/fatigue : Visit 8	40 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Energy/fatigue : Visit 9	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Energy/fatigue : Visit 10	55 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Emotional Well-being : Visit 1	84 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Emotional Well-being : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Emotional Well-being : Visit 8	88 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Emotional Well-being : Visit 9	92 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Emotional Well-being : Visit 10	76 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Social Functioning : Visit 1	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Social Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Social Functioning : Visit 8	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Social Functioning : Visit 9	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Social Functioning : Visit 10	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Pain : Visit 1	32.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Pain : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Pain : Visit 8	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Pain : Visit 9	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 Pain : Visit 10	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 General Health : Visit 1	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 General Health : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 General Health : Visit 8	35 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 General Health : Visit 9	31.25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #2 General Health : Visit 10	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 Physical Functioning : Visit 1	16.67 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 Physical Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 Physical Functioning : Visit 8	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 Physical Functioning : Visit 9	40 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 Physical Functioning : Visit 10	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Role-physical : Visit 1	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Role-physical : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Role-physical : Visit 8	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Role-physical : Visit 9	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Role-physical : Visit 10	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Role-emotional : Visit 1	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Role-emotional : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Role-emotional : Visit 8	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Role-emotional : Visit 9	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Role-emotional : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Energy/fatigue : Visit 1	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Energy/fatigue : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Energy/fatigue : Visit 8	5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Energy/fatigue : Visit 9	5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Energy/fatigue : Visit 10	5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Emotional Well-being : Visit 1	88 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Emotional Well-being : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Emotional Well-being : Visit 8	68 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Emotional Well-being : Visit 9	68 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3: Emotional Well-being : Visit 10	72 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 : Social Functioning : Visit 1	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 : Social Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 : Social Functioning : Visit 8	62.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 : Social Functioning : Visit 9	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 : Social Functioning : Visit 10	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 Pain : Visit 1	90 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 Pain : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 Pain : Visit 8	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 Pain : Visit 9	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 Pain : Visit 10	90 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 : General Health : Visit 1	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 : General Health : Visit 5	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 : General Health : Visit 8	31.25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 : General Health : Visit 9	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #3 : General Health : Visit 10	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Physical Functioning : Visit 1	45 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Physical Functioning : Visit 5	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Physical Functioning : Visit 8	33.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Physical Functioning : Visit 9	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Physical Functioning : Visit 10	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Role-physcial : Visit 1	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Role-physcial : Visit 5	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Role-physcial : Visit 8	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Role-physcial : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Role-physcial : Visit 10	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Role-emotional : Visit 1	33.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Role-emotional : Visit 5	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Role-emotional : Visit 8	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Role-emotional : Visit 9	33.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Role-emotional : Visit 10	33.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Energy/fatigue : Visit 1	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Energy/fatigue : Visit 5	35 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Energy/fatigue : Visit 8	35 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Energy/fatigue : Visit 9	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Energy/fatigue : Visit 10	35 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Emotional Well-being : Visit 1	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Emotional Well-being : Visit 5	56 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Emotional Well-being : Visit 8	72 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Emotional Well-being : Visit 9	66.67 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Emotional Well-being : Visit 10	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Social Functioning : Visit 1	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Social Functioning : Visit 5	37.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Social Functioning : Visit 8	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Social Functioning : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Social Functioning : Visit 10	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Pain : Visit 1	22.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Pain : Visit 5	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Pain : Visit 8	67.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Pain : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : Pain : Visit 10	55 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : General Health : Visit 1	35 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : General Health : Visit 5	35 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : General Health : Visit 8	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : General Health : Visit 9	40 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #4 : General Health : Visit 10	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Physical Functioning : Visit 1	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Physical Functioning : Visit 5	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Physical Functioning : Visit 8	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Physical Functioning : Visit 9	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Physical Functioning : Visit 10	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Role-physical : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Role-physical : Visit 5	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Role-physical : Visit 8	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Role-physical : Visit 9	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Role-physical : Visit 10	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Role-emotional : Visit 1	33.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Role-emotional : Visit 5	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Role-emotional : Visit 8	33.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Role-emotional : Visit 9	33.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Role-emotional : Visit 10	33.33 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Energy/fatigue : Visit 1	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Energy/fatigue : Visit 5	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Energy/fatigue : Visit 8	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Energy/fatigue : Visit 9	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Energy/fatigue : Visit 10	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Emotional Well-being : Visit 1	72 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Emotional Well-being : Visit 5	76 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Emotional Well-being : Visit 8	68 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Emotional Well-being : Visit 9	64 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Emotional Well-being : Visit 10	68 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Social Functioning : Visit 1	12.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Social Functioning : Visit 5	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Social Functioning : Visit 8	37.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Social Functioning : Visit 9	12.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Social Functioning : Visit 10	12.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Pain : Visit 1	22.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Pain : Visit 5	35 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Pain : Visit 8	22.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Pain : Visit 9	32.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: Pain : Visit 10	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: General Health : Visit 1	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: General Health : Visit 5	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: General Health : Visit 8	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: General Health : Visit 9	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #5: General Health : Visit 10	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Physical Functioning : Visit 1	22.22 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Physical Functioning : Visit 5	27.78 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Physical Functioning : Visit 8	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Physical Functioning : Visit 9	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Physical Functioning : Visit 10	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Role-physical : Visit 1	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Role-physical : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Role-physical : Visit 8	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Role-physical : Visit 9	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Role-physical : Visit 10	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Role-emotional : Visit 1	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Role-emotional : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Role-emotional : Visit 8	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Role-emotional : Visit 9	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Role-emotional : Visit 10	33.3 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Energy/fatigue : Visit 1	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Energy/fatigue : Visit 5	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Energy/fatigue : Visit 8	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Energy/fatigue : Visit 9	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Energy/fatigue : Visit 10	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Emotional Well-being : Visit 1	46.67 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Emotional Well-being : Visit 5	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Emotional Well-being : Visit 8	64 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Emotional Well-being : Visit 9	64 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Emotional Well-being : Visit 10	36 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Social Functioning : Visit 1	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Social Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Social Functioning : Visit 8	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Social Functioning : Visit 9	37.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Social Functioning : Visit 10	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Pain : Visit 1	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Pain : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Pain : Visit 8	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Pain : Visit 9	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: Pain : Visit 10	55 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: General Health : Visit 1	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: General Health : Visit 5	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: General Health : Visit 8	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: General Health : Visit 9	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #6: General Health : Visit 10	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Physical Functioning : Visit 1	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Physical Functioning : Visit 5	55 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Physical Functioning : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Physical Functioning : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Physical Functioning : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Role-physical : Visit 1	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Role-physical : Visit 5	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Role-physical : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Role-physical : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Role-physical : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Role-emotional : Visit 1	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Role-emotional : Visit 5	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Role-emotional : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Role-emotional : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Role-emotional : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Energy/fatigue : Visit 1	65 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Energy/fatigue : Visit 5	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Energy/fatigue : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Energy/fatigue : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Energy/fatigue : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Emotional Well-being : Visit 1	72 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Emotional Well-being : Visit 5	88 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Emotional Well-being : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Emotional Well-being : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Emotional Well-being : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Social Functioning : Visit 1	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Social Functioning : Visit 5	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Social Functioning : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Social Functioning : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Social Functioning : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Pain : Visit 1	77.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Pain : Visit 5	77.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Pain : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Pain : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: Pain : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: General Health : Visit 1	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: General Health : Visit 5	35 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: General Health : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: General Health : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #7: General Health : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Energy/fatigue : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Energy/fatigue : Visit 8	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Energy/fatigue : Visit 9	35 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Energy/fatigue : Visit 10	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Emotional Well-being : Visit 1	56 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Emotional Well-being : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Emotional Well-being : Visit 8	64 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Emotional Well-being : Visit 9	52 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Emotional Well-being : Visit 10	92 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Social Functioning : Visit 1	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Social Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Social Functioning : Visit 8	62.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Social Functioning : Visit 9	62.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Social Functioning : Visit 10	62.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 Pain : Visit 1	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 General Health : Visit 1	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 General Health : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 General Health : Visit 8	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 General Health : Visit 9	40 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #14 General Health : Visit 10	60 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Physical Functioning : Visit 1	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Physical Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Physical Functioning : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Physical Functioning : Visit 9	5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Physical Functioning : Visit 10	11.11 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Role-physical : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Role-physical : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Role-physical : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Role-physical : Visit 9	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Role-physical : Visit 10	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Role-emotional : Visit 1	66.67 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Role-emotional : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Role-emotional : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Role-emotional : Visit 9	66.67 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Role-emotional : Visit 10	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Energy/fatigue : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Energy/fatigue : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Energy/fatigue : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Energy/fatigue : Visit 9	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Energy/fatigue : Visit 10	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Emotional Well-being : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Emotional Well-being : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Emotional Well-being : Visit 9	88 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Emotional Well-being : Visit 10	80 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Social Functioning : Visit 1	37.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Social Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Social Functioning : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Social Functioning : Visit 9	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Social Functioning : Visit 10	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Pain : Visit 1	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Pain : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Pain : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Pain : Visit 9	70 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 Pain : Visit 10	22.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 General Health : Visit 1	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 General Health : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 General Health : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 General Health : Visit 9	15 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #15 General Health : Visit 10	10 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Physical Functioning : Visit 1	30 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Physical Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Physical Functioning : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Physical Functioning : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Physical Functioning : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Role-physical : Visit 1	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Role-physical : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Role-physical : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Role-physical : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Role-physical : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Role-emotional : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Role-emotional : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Role-emotional : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Role-emotional : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Role-emotional : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Energy/fatigue : Visit 1	20 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Energy/fatigue : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Energy/fatigue : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Energy/fatigue : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Energy/fatigue : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Emotional Well-being : Visit 1	48 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Emotional Well-being : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Emotional Well-being : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Emotional Well-being : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Emotional Well-being : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Social Functioning : Visit 1	0 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Social Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Social Functioning : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Social Functioning : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Social Functioning : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Pain : Visit 1	22.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Pain : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Pain : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Pain : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 Pain : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 General Health : Visit 1	25 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 General Health : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 General Health : Visit 8	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 General Health : Visit 9	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #16 General Health : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Physical Functioning : Visit 1	95 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Physical Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Physical Functioning : Visit 8	88.89 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Physical Functioning : Visit 9	85 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Physical Functioning : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Role-physical : Visit 1	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Role-physical : Visit 8	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Role-physical : Visit 9	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Role-physical : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Role-emotional : Visit 1	66.67 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Role-emotional : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Role-emotional : Visit 8	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Role-emotional : Visit 9	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Role-emotional : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Energy/fatigue : Visit 1	70 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Energy/fatigue : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Energy/fatigue : Visit 8	40 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Energy/fatigue : Visit 9	35 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Energy/fatigue : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Emotional Well-being : Visit 1	96 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Emotional Well-being : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Emotional Well-being : Visit 8	76 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Emotional Well-being : Visit 9	76 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Emotional Well-being : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Social Functioning : Visit 1	87.5 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Social Functioning : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Social Functioning : Visit 8	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Social Functioning : Visit 9	50 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Social Functioning : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Pain : Visit 1	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Pain : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Pain : Visit 8	100 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Pain : Visit 9	75 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 Pain : Visit 10	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 General Health : Visit 1	55 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 General Health : Visit 5	NA Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 General Health : Visit 8	70 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 General Health : Visit 9	55 Average Score
Bortezomib	Short Form (SF)-36 Health Survey	Pt #17 General Health : Visit 10	NA Average Score

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026

A Proposal to Test the Efficacy and Tolerability of Bortezomib in Pulmonary Chronic GVHD

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Outcome results

Change in Pulmonary Function as Measured by Forced Expiratory Volume in 1 Second (FEV1) Decline

Exercise Tolerance- 6 Minute Walk

Short Form (SF)-36 Health Survey