Lung Transplantation
Conditions
Keywords
inspiratory muscle training, pulmonary rehabilitation
Brief summary
Lung transplantation (LT) is now an established treatment option for patients with a wide variety of end-stage lung diseases- aims to improve quality of life and survival. Pulmonary rehabilitation (PR) is widely recognized as an important component of care of patients with chronic obstructive pulmonary disease (COPD), it improves dyspnea, exercise tolerance, quality of life, and reduces healthcare resource utilization. The goal of pulmonary rehabilitation following lung transplantation is to enhance the physiological and functional benefits resulting from surgery. Inspiratory muscle Training (IMT) is defined as any intervention with the goal of training the inspiratory muscles. IMT can improve inspiratory muscles strength, endurance and exercise capacity in adults with COPD. IMT provides additional benefits to patients undergoing PR program and is worthwhile even in patients who have already undergone a general exercise reconditioning (GER) program. IMT will provide additional benefits (together or without) PR to patients following lung transplantation. No formal guidelines exist regarding the optimal methods of exercise training component of pulmonary rehabilitation for patients recovering from lung transplantation. This study will evaluate the unique influence of IMT in Patients Following Lung Transplantation.
Detailed description
The post lung transplant patients will participate in a rehabilitation program for 6 months. Participants in the proposed study will belong to one of four intervention groups: 1. Conventional or regular pulmonary rehabilitation program alone(an exercise program that consist 3 main components: aerobic conditioning, resistance training, and flexibility exercises). 2. Very low load IMT(sham IMT) alone. 3. Conventional or regular pulmonary rehabilitation program + Targeted inspiratory resistive or threshold IMT. 4. Targeted inspiratory resistive or threshold IMT alone.
Interventions
BEHAVIORALConventional or regular pulmonary rehabilitation program alone
Conventional or regular pulmonary rehabilitation program alone
DEVICEvery low load IMT (sham IMT) alone
very low load IMT (sham IMT) alone
DEVICEConventional or regular pulmonary rehabilitation program + targeted inspiratory resistive or threshold IMT
Conventional or regular pulmonary rehabilitation program + targeted inspiratory resistive or threshold IMT
DEVICETargeted inspiratory resistive or threshold IMT alone
Targeted inspiratory resistive or threshold IMT alone
Sponsors
Rabin Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Post lung transplant patients attending the pulmonary Institute , will be invited to participate,They will be co-operative and able to perform spirometry; and other lung tests. * Patients will be stable clinically,for at least one month,the patients will be all new to an IMT program.
Exclusion criteria
* Patients with cardiac disease,poor compliance,or requirement of supplemental oxygen.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| maximal exercise capacity | 9 months after starting interventions | at 9 months after starting interventions |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lung function (FEV1, FVC) | 9 months after starting interventions | 9 months after starting interventions |
Countries
Israel
Contacts
Primary ContactProf Mordechai R. Kramer M.D R Kramer, MD
Outcome results
None listed