Primary Sclerosing Cholangitis (PSC)
Conditions
Keywords
Primary Sclerosing Cholangitis, PSC, Cholestatic Liver Disease
Brief summary
Primary Sclerosing Cholangitis (PSC) is a progressive liver disorder of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PSC. This study is being done to investigate whether genes make people more likely to develop PSC. Discovery of these genes will help us to better understand how PSC developes and subsequently, to apply new approaches for its prevention, diagnosis and treatment.
Interventions
GENETICGenetic Analysis
Perform Genome Wide Association Studies.
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
5 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Men, Women, and Children between the ages of 5-90 with a history of PSC. * PSC patients who have had a liver transplant are eligible. * Family members (1st degree relatives) of enrolled PSC patients are eligible.
Exclusion criteria
* Individuals with no history of PSC or those unable to provide consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mapping of Susceptibility Genes in Adult Chronic Cholestatic Liver Diseases | — | Adult chronic cholestatic liver diseases, such as Primary Sclerosing Cholangitis (PSC), are progressive liver disorders of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PSC. This study is being done to investigate whether genes (the inherited genetic material passed from parents to their children) make people more likely to develop PSC. Discovery of these proposed genes will help us to better understand how PSC progresses, |
Countries
United States
Outcome results
None listed