Primary Biliary Cirrhosis
Conditions
Keywords
Primary Biliary Cirrhosis, PBC, Cholestatic Liver Disease
Brief summary
Primary Biliary Cirrhosis (PBC) is a progressive liver disorder of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PBC. This study is being done to investigate whether genes make people more likely to develop PBC. Discovery of these proposed genes will help us better understand how PBC developes, and subsequently, to apply new approaches for its prevention, diagnosis and treatment.
Interventions
GENETICGenetic Analysis
Perform Genome Wide Association Studies.
Sponsors
Mayo Clinic
Study design
Observational model
FAMILY_BASED
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Men and women between the ages of 18-90 who have a history of PBC. * PBC patients who have undergone a liver transplant are eligible. * Family members (1st degree relatives) of enrolled PBC patients are eligible.
Exclusion criteria
* Individuals with no history of PBC or those unable to provide consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mapping of Susceptibility Genes in Adult Chronic Cholestatic Liver Diseases | — | Adult chronic cholestatic liver diseases, such as Primary Biliary Cirrhosis (PBC), are progressive liver disorders of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PBC. This study is being done to investigate whether genes (the inherited genetic material passed from parents to their children) make people more likely to develop PBC. Discovery of these proposed genes will help us to better understand how PBC progresses, and subsequently, to apply new approaches for its prevention, diagnosis and treatment. |
Countries
United States
Outcome results
None listed