PD-1/PD-L1 Pathway Study on Septic Patients

PD-1/PD-L1 Pathway in T Lymphocyte Apoptosis and Monocyte Dysfunction in Septic Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01161745

Enrollment

Registered

2010-07-14

Start date

2008-12-31

Completion date

2010-04-30

Last updated

2010-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Keywords

sepsis

Brief summary

The investigators want to identify that whether PD-1/PD-L1 pathway will change in human sepsis, and whether PD-1/PD-L1 pathway play an important role in sepsis induced immunosuppression.

Detailed description

First, we will detect PD-L1 expression on PBMC of septic patients and healthy controls. Second, blockade of PD-1/PD-L1 pathway in vitro and stimulate with some biomolecules and then analyze the PBMC function and apoptosis by flow cytometry. Then, compare with healthy controls and find the differences.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* patients who develop sepsis

Exclusion criteria

* patients with cirrhosis or renal dysfunction * patients with dyscrasia * patients with autoimmunity diseases * patients with severe cardiac and pulmonary diseases * patients with hematological diseases * patients with diabetes mellitus * patients with malignant tumors

Outcome results