Blood Pressure, Cardiovascular Disease, Vegetables
Conditions
Keywords
vegetable juice, cardiovascular, blood pressure
Brief summary
The purpose of the investigators study is to investigate the impact of a commercial vegetable juice on dietary vegetable intake and select cardiovascular risk factors in a generally healthy population. The study was a 12 week study with 3 groups who received 0, 8 or 16 fluid ounces daily of vegetable juice, along with education on the DASH (Dietary Approaches to Stop Hypertension) diet. All participants came in for 3 study visits at 0, 6 and 12 weeks into the study.
Interventions
OTHERVegetable Juice
Participants consumed vegetable juice daily in the amount of 0, 8 or 16 fluid ounces.
Sponsors
University of California, Davis
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
\*\*\*Inclusion Criteria\*\*\* * Age 40 to 65 yrs * Subject's body mass index is between 18.5 - 34.9 kg/m2 * Subject is willing and able to comply with the study protocols * Subject is willing to consume a vegetable-based beverage daily for three months \*\*\*
Exclusion criteria
\*\*\* * Physical signs of health impairment * Uncontrolled diabetes or hypertension * Pregnant or lactating * Active tuberculosis or lung disease (i.e. COPD) * Renal or Liver disease * Heart Disease, which includes Cardiovascular events and Stroke * Cushing's syndrome * Exercise trained individuals * History of psychiatric disorders i.e. schizophrenia or bi-polar or depression treated with antidepressants within the last 1 year * Anxiety medications * Use of MAOI inhibitors within the last 1 year (e.g., phenelzine (Nardil), tranylcypromine (Parnate), etc.) * Quality of life score of 21 or above * Routine use of prescription drugs or over-the counter medications, which may potentially modulate the outcome of this study; including antibiotics, aspirin and aspirin-containing formulations, COX-2 inhibitors, antihistamines, corticosteroids, erectile dysfunction drugs * Asthma (can be worsened by mild to moderate food allergies) * Indications of substance or alcohol abuse within the last 3 years * The volunteer is undergoing nicotine cessation therapy * Laboratory values outside the reference range if determined to be clinically significant by Dr. M. Eric Gershwin * Individuals with known salt-sensitive hypertension * History of stage 1 high blood pressure defined as systolic \> 140 and diastolic \> 90, with or without use of HTN medications * Multi-Vitamin use other than a One-A-Day essential * Use of herbal or plant-based supplements; omega-3 fatty acids, and fish oils and unwilling to discontinue use while participating in the study * Allergies to vegetables
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dietary Vegetable Intake | 6 and 12 weeks |
| Dietary Nutrient Intake (vitamins & minerals) | 6 and 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Selected Cardiovascular Risk Factors (lipids, blood pressure, TBARS/oxidative stress) | 0, 6 and 12 weeks |
Countries
United States
Outcome results
None listed