Migraine
Conditions
Keywords
migraine patients
Brief summary
Mechanism-based choice of therapy for pain: Can successful prevention of migraine be coupled to a psychophysical pain modulation profile?
Interventions
DRUGAmitriptyline
Initial dose of 12.5mg will be given for 2 days. Then, daily 25mg will be taken for additional 8 weeks
DRUGTopiramate
For the first 5 days of treatment 25mg is prescribed and should be ingested in one evening dose. For another 5 days, 25g dose should be taken twice a day (morning and evening). For the next 5 days, morning dose will be 25mg; evening dose will be 50mg. For the remaining 6 weeks of treatment, a dose of 50mg twice a day will be advised
Sponsors
Rambam Health Care Campus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* female and male migraine patients with a number of month attacks ≥ 4, * age 18-75, * without any other chronic pain.
Exclusion criteria
* any migraine preventive treatment for last 6 month & psychiatric, * language or cognitive dysfunction precluding use of psychophysics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Therapeutic response to the analgesic drugs | 2 months |
Countries
Israel
Outcome results
None listed