Contrast Induced Nephropathy
Conditions
Keywords
CIN STEMI
Brief summary
OBJECTIVE: To evaluate the efficacy of prevention of contrast induced nephropathy in patients with ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention. DESIGN: Prospective study. SETTING: Three-center study Acute kidney injury was defined as a rise in creatinine \>25% from baseline Serum creatinine will be measured at baseline and each day for the following 3 days and at 30 days. Patients will be randomised to: 1. Standard treatment 2. Standard treatment + acetylcystein for 2 days 3. Standard treatment + Sodium bicarbonate 500 ml / followed by 100 ml/h for 5 hours 4. Standard treatment + acetylcystein for 2 days + Sodium bicarbonate 500 ml / followed by 100 ml/h for 5 hours
Interventions
OTHERHydration
Saline hydration
DRUGAcetylcysteine
Acetylcystein tablets for 2 days
DRUGSodium bicarbonate
Sodium bicarbonate 500 ml followed by 100 ml/hour for 5 hours
DRUGCombined Acetylcystein and Sodium Bicarbonate
Sodium bicarbonate 500 ml followed by 100 ml/hour for 5 hours combined with acetylcystein tablets for 2 days
Sponsors
Odense University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* STEMI patients treated with primary PCI
Exclusion criteria
* Cardiogenic shock
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevention of contrast induced nephropathy in STEMI patients treated with primary PCI | from baseline to day 3 | Rise in creatinine \>25% from baseline to day 3 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prevention of contrast induced nephropathy in STEMI patients treated with primary PCI | from baseline to day 30 | Rise in creatinine \>25% from baseline to day 30 |
Countries
Denmark
Outcome results
None listed