The Rate of C-reactive Protein (CRP) Increase as a Marker for Bacterial Infections in Children

CRP Velocity as a Marker for Bacterial Infections in Children

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01159470

Acronym

CRPv

Enrollment

200

Registered

2010-07-09

Start date

2010-09-30

Completion date

2011-09-30

Last updated

2010-07-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial Infections, Viral Infection

Keywords

CRP velocity

Brief summary

Fever is one of the most common problems in pediatrics. Differentiating between bacterial infections, that require antibiotic therapy, and viral infections that resolve on their own is an important challenge for physicians. C-reactive protein (CRP) is a protein that increases in response to inflammation and its level is generally higher in bacterial infections compared to viral infections. it can be measured by a simple blood test, however its utility as a sole marker for bacterial infection is limited. The hypothesis of the study is that measuring CRP velocity, e.g the value of CRP divided by the hours since the fever started will improve the utility of CRP for the diagnosis of bacterial infections in children.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 5 Years

Healthy volunteers

Inclusion criteria

* children less than 5 years of age, * children with no comorbidities and fever \> 38 for at least 24 hours, and * children with no previous antibiotic therapy.

Exclusion criteria

* HIV, * immunosuppressive conditions, * antibiotic therapy.

Outcome results