Anesthesia, General, Laparoscopic Surgery
Conditions
Keywords
Anesthesia, General, Propofol, Pregabalin, Preoperative care, Laparoscopic surgery
Brief summary
The primary issue is to determine whether preoperatively administered pregabalin decreases the necessary dose of propofol during induction of general anesthesia. The investigators secondary issue is to test if preoperatively administered pregabalin decreases anxiety.
Interventions
DRUGPregabalin
Preoperative administration of pregabalin vs placebo 1 hour before surgery
Sponsors
Université de Sherbrooke
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Laparoscopic gynaecologic surgery * Age 18-40 years * ASA class I or II * Body mass index 18-30
Exclusion criteria
* Allergic to pregabalin or gabapentin * Chronic renal failure * Alcohol or drug abuse * Chronic analgesic use other than acetaminophen or NSAID * Already taking gabapentin, pregabalin, benzodiazepin or antidepression drug * Known neurological deficiency * Suspected difficult intubation or ventilation * Atypical pseudocholinesterases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Propofol induction dose | 1 hour | Evaluation of the hpreoperative pregabalin Vs placebo effect on propofol induction dose needed to induce general anesthesia assessed by entropy in gynaecologic patients undertaking minor surgical procedure. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Preoperative anxiety | 1 hour | Evaluation of the effect of pregabalin Vs placebo on preoperative anxiety |
Countries
Canada
Outcome results
None listed