Fibrin Glue vs. Suture in Pterygium Surgery

Fibrin Glue vs. Vicryl Suture in Pterygium Surgery With Conjunctival Auto-graft

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01158014

Enrollment

Registered

2010-07-08

Start date

2014-01-31

Completion date

2016-06-30

Last updated

2017-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Conjunctival Autograft

Keywords

pterygium, conjunctival graft, recurrence, primary pterygium

Brief summary

The use of Fibrin glue to place conjunctival graft will be as effective as suturing the graft, but will require much less operative time and will be better tolerated by the patients.

Detailed description

Pterygium surgery requires removal of the pterygia from cornea and conjunctiva and an additional technique to prevent recurrence which may be as high as 50%. Suturing a conjunctival auto-graft has become one of the most popular and effective methods in preventing recurrence. However suturing requires long operative time (10-20 minutes with removal alone less than 5 minutes) and requires sutures removal after 1-2 weeks which is very inconvenient to the patient. Using Fibrin Glue (Quixil) has been used in several places in pterygium surgery and we believe it will be as effective as suturing the graft, will use much less OR time (reduce surgery time from 40 minutes to 20-25 minutes) and will be less expensive since 2 ml glue (around 80US$) suffice for 10 cases, while one vicryl suture costs around 34 US$.

Interventions

PROCEDUREFibrin Glue, Quixil

quixil 0.1 ml

PROCEDURESuture

vicryl 10/0

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* primary pterygium * healthy subject * ability to attend follow-up visits

Exclusion criteria

* recurrent pterygium * underwent previous surgery / intervention to treat pterygium * ocular surface disease 0 minor

Design outcomes

Primary

Measure	Time frame	Description
Pterygium recurrence	one year	Recurrence normally occurs 1-6 months after surgery. Success is achieved if ptergium does not recur after one year.

Secondary

Measure	Time frame	Description
operation time	one year	suturing a conjunctival graft takes 15-10 minutes while gluing only 5 minutes, we believe that by lowering OR time, total costs of surgery are less

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026