Oral Contraceptive Pill and GnRH Antagonist Versus Long Protocol in IVF Patients

Cycle Planning With OCP in GnRH Antagonists Cycles Versus Long Protocol in Good Prognosis IVF Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01157754

Acronym

Larganta

Enrollment

115

Registered

2010-07-07

Start date

2009-06-30

Completion date

2010-06-30

Last updated

2015-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

Infertility patients requiring IVF, good prognosis

Brief summary

Recent controversy has arisen regarding the use of the pill for cycle planning in GnRH antagonist IVF cycles. The investigators performed this study to compare such a protocol with the gold-standard still today, which is the long-agonist protocol with no previous use of the pill.

Interventions

DRUGlevonorgestrel and ethynilestradiol

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 38 Years

Healthy volunteers

Inclusion criteria

* 1st or 2nd IVF cycle * BMI \<30 kg/m2 * regular menstrual cycles * basal FSH \<10 IU and E2 \<60 pg/ml

Exclusion criteria

* Polycystic ovaries * endometriosis * previous ovarian surgery * previous low ovarian response

Design outcomes

Primary

Measure	Time frame
implantation rate	2 weeks after the embryo transfer

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026