Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
Conditions
Keywords
60 patients scheduled to have a colorectal surgery, recruit at Montreal General Hospital
Brief summary
Patients receiving perioperative intravenous lidocaine, post operative restoration of bowel movement will be faster and decrease pain intensity, opioid consumption and side effects, length of hospital stay; probably as a result of a significant opioid sparing and attenuated inflammatory response.
Detailed description
The aim of this study is to assess whether perioperative intravenous lidocaine has an impact on the early postoperative physical activity recovery of patients scheduled for laparoscopic colorectal resection. The study focuses on patients with colorectal disease, which receive the laparoscopic (assisted) surgical approach. It is hypothesized that in those patients receiving perioperative and post-operative intravenous lidocaine, bowel function recovery will be faster, probably as a result of a significant opioid sparing, less pain and attenuated inflammatory response.
Interventions
DRUGLidocaine
1% Lidocaine 1mg/kg/hr IV drip x 48hr
PROCEDUREThoracic epidural block
0.1% Epidural bupivacaine + Morphine 0.02 mg/ml drip via epidural x48 hr
Sponsors
McGill University Health Centre/Research Institute of the McGill University Health Centre
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* scheduled to undergo laparoscopic colorectal resection
Exclusion criteria
* patients who have trouble to understand, read or communicate either in French or in English * dementia * patients suffering from severe physical disability (arthritis, neuromuscular dysfunction, stroke, paraplegia) or inability to walk or conduct daily activity * patients suffering from severe cardiac or respiratory disease (status ASA IV * patients suffering from metastatic carcinoma * patients who have a history of chemoradiation within the six months preceding surgery * allergy to lidocaine * morbid obesity * patients with chronic opioid use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Restoration of bowel function | 72 hours after an operation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain intensity | within 72 hours after an operation | Visual analog score pain (from 0-10) at rest, on walking and coughing at 24, 48 and 72 hours after an operation are assessed. |
Countries
Canada
Outcome results
None listed