Systematic Review of Antiretroviral Treatments for Chronic Hepatitis B (CHB)

A Systematic Review of Literature on Common Antiretroviral Treatments Against Hepatitis B Virus (HBV)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01155427

Enrollment

100

Registered

2010-07-01

Start date

2009-05-31

Completion date

2010-04-30

Last updated

2010-07-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatitis B, Chronic

Brief summary

The purpose of this study is to support the clinical value of entecavir by assessing the relationship between viral load and histological improvement.

Detailed description

Systematic review of prospective clinical trials

Interventions

None listed

Study design

Observational model

COHORT

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with CHB diagnosis and no co-infection with Hep A, Hep C, Hep D, or HIV * Age 16 years or older * No post-transplant patients * RCT, non-randomized trials, prospective cohort studies, prospectively analyses case series published since 2003 * At least one arm of trial must include monotherapy with entecavir, lamivudine, tenofovir, adefovir, or telbivudine * Study arms must include at least 10 patients * Follow-up of at least 48 weeks * Published results available in English language

Exclusion criteria

* N/A

Design outcomes

Primary

Measure	Time frame
Viral load	—
Histological improvement	—

Outcome results