Schizophrenia
Conditions
Keywords
dopamine, first episode, reward, cognition, MRI, fMRI, PPI, P300, P50 gating, endophenotypes
Brief summary
The investigators want to relate disturbances in first-episode schizophrenic patients in (dopaminergic) D2 receptors, brain structure, brain function, and information processing to each other and to psychopathology. Additionally, the investigators want to examine the influence of D2 receptor blockade on these disturbances. The investigators expect disturbances in the dopaminergic system at baseline to correlate with specific structural and functional changes and with disruption in information processing as measured with psychophysiological and neurocognitive methods - and investigators expect D2 receptor blockade to reverse some of the functional and cognitive impairments.
Detailed description
The study is designed as a 6 week case-control follow-up study of 70 AN FE pt. with SCZ and 70 controls matched with regard to age, gender, and parental socio-economic status. All subjects will be examined with a diagnostic interview (SCAN, Schedule for Clinical Assessment in Neuropsychiatry), medical and family history, and physical examination before inclusion. At baseline all subjects will be examined with single photon emission computed tomography (SPECT), MRI, fMRI, psychophysiology, neurocognition. In addition, they will be screened for drugs, genetic testing, and ECG. Patients will further be examined with clinical validated rating scales to measure psychopathology, subjective well-being, and side-effects. After a period of 6 weeks all assessments are repeated. During that period patients will be treated with amisulpride, while healthy controls will receive no treatment at all. Efficacy of antipsychotic treatment will be evaluated after this initial period of 6 weeks. Based on this evaluation it will be decided to either continue the current (amisulpride) antipsychotic treatment, or to switch to aripiprazole. Efficacy of aripiprazole is evaluated on a monthly basis, if the patient does not respond well enough, than the treatment will be adapted individually. Regardless of treatment, all subjects will be re-assessed in the same test battery as mentioned above, except for SPECT and fMRI, after a period of 6, 12, and 24 months. The developement in specific disturbances and the relationship between these will be analysed.
Interventions
DRUGamisulpride
Individually dosed, according to symptoms, for a period of 6 weeks
DRUGaripiprazole
Individually dosed, according to symptoms, for a period of 6 weeks
Sponsors
Glostrup University Hospital, Copenhagen
Rigshospitalet, Denmark
Institute of Psychiatry, London
UMC Utrecht
Copenhagen Hospital Corporation
University of Copenhagen
Study design
Allocation
NON_RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
For patients: meeting diagnostic criteria for schizophrenia according to ICD 10 or DSM IV antipsychotic naive The controls will be matched to the patients according to gender age and parental socio-economic status. \-
Exclusion criteria
Patients: mental retardation, other chronic diseases, use of antidepressive medicine during the last month,being pregnant, on going substance abuse Controls: psychiatric diagnosis, psychiatric diagnosis in first-degree relatives,on going drug abuse, mental retardation -
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relationship between specific neuropsychiatric measures and improvement on PANSS scores | 6 weeks of medical treatment |
Secondary
| Measure | Time frame |
|---|---|
| Time/dose improvement on PPI and other psychophysiological measures of early information processing after D2 blockade | Baseline, 2 and 6 weeks, 6,12,24 months |
| Disturbances in reward related fMRI BOLD response in antipsychotic naive schizophrenic patients | Baseline and 6 weeks follow up |
| The relation between D2 binding potential (SPECT) and reward related brain activity (fMRI BOLD response) before and after D2 blockade | Baseline, 6 weeks |
| Cognitive differences at baseline and changes over time after D2 blockade | Baseline, 6 weeks, 6,12,24 months |
| The effect of D2 blockade on reward related fMRI BOLD response | 6 weeks of medical treatment |
| Structural changes in grey and white matter before and after D2 blockade | 6 weeks, 6, 12 and 24 months, |
Countries
Denmark
Outcome results
None listed