Nutrition, Physiology
Conditions
Keywords
ingestive behavior
Brief summary
The project aims to precisely quantify the postprandial amino acid utilization of egg proteins in vivo in humans, and also to assess their satiating power, in relation with nutrient postprandial waves and incretin secretions. For that purpose, 2 independent studies are conducted. The first one is realized using stable isotopes on 8 volunteers ingesting an egg test meal. The second one is a cross over design performed on 30 volunteers to compare the satiating effect of 2 equivalent snacks: whole eggs or cottage cheese.
Interventions
DIETARY_SUPPLEMENTEgg snack
subject consume 4 cooked whole eggs, providing 380 kcal
DIETARY_SUPPLEMENTCottage cheese
Subjects consume 200 g of cottage cheese, providing 380 kcal
Sponsors
National Research Agency, France
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers * BMI between 18 and 25
Exclusion criteria
* Allergy to egg or milk protein * Digestive or metabolic pathology * Positiveness to HIV, Hepatitis B and C * Smokers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| energy intake at lunch following the snack | — | — |
| Dietary amino acid utilization | — | transfer of stables isotopes used as intrinsic markers of egg proteins to metabolic pools |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| plasma incretin concentrations | — | insulin, glucagon, GLP-1, PYY, ghrelin, GIP |
| postprandial nutrient waves | — | plasma glucose, cholesterol, triglyceride, urea |
| neoglucogenesis | — | Endogenous production of glucose and contribution of dietary amino acids |
Countries
France
Outcome results
None listed