Metabolic Syndrome
Conditions
Keywords
polyphenols omega-3 postprandial lipemia adipose tissue
Brief summary
The aim of this study is to explore if a 8-weeks dietary intervention with polyphenols and omega 3 fatty acids (alone or combined) may be effective on postprandial lipids metabolism and other cardiovascular risk factors in people at high cardiovascular risk.
Detailed description
Fish consumption is associated with a lower cardiovascular risk and dietary supplementation with ω-3 fatty acids reduces plasma triglyceride levels. The mechanisms of action of ω-3 fatty acids are currently not completely understood. It has been hypothesized that polyunsaturated ω-3 fatty acids beneficial effects may be mediated through their ability to facilitate plasmalogen replenishment. Polyphenols are associated with beneficial effects on some cardiovascular risk factors, in particular with a reduced lipid oxidation. Less data are available on their effects on lipid metabolism. Recent data suggest that these effects could be mediated by changes in plasmalogen levels. The effects on lipid metabolism of combining the two dietary approaches (ω-3 fatty acids and polyphenols) are not known. While developed populations live for the most part in the postprandial state, much of the information on lipid metabolism refers to fasting condition. Dietary Intervention Study Design Eighty people at high cardiovascular risk randomly assigned to one of the four different nutritional 8-week interventions: (A) Control diet poor in omega-3 fatty acids and polyphenols (B) Diet rich in omega-3 fatty acids (C) Diet rich in polyphenols (D) Diet rich in omega-3 fatty acids and polyphenols
Interventions
fish at least 3 times per week, large leaf vegetables
OTHERDiet rich in polyphenols
extra virgin olive oil, green tea, berries,fruits rich in polyphenols, dark chocolate, decaffenated coffee
OTHERControl diet
low content of omega-3 fatty acids and polyphenols (low intake of fish, nuts and legumes,oil rich in monounsaturated fatty acids, vegetables and fruits poor in polyphenols)
OTHERdiet rich in omega-3 and polyphenols
Fish at least 3 times x week,large leaf vegetables + extra virgin olive oil, green tea, berries,fruits rich in polyphenols, dark chocolate, decaffenated coffee
Sponsors
Federico II University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* bmi \>25\<35 kg/m2 * High waist circumference (men \>102 cm, women \>88 cm) + one the following components of metabolic syndrome : Fasting plasma triglycerides ≥150 mg/dl Fasting HDL-col \<40 mg/dl (men) and \<50 mg/dl (women) Fasting plasma glucose 100-125 mg/dl
Exclusion criteria
* Fasting plasma triglycerides ≥400 mg/dl and cholesterol \>270 mg/dl * Cardiovascular events (AMI and/or stroke) in the last 6 months * Diabetes mellitus * Regular intensive physical activity * Kidney (serum creatinine \>1.7 mg/dl) and liver (transaminases \>double) * Hypolipidemic or antinflammatory drugs * Anemia (Hb \<12 g/dl) or any other chronic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incremental AUC after a test meal of triglycerides concentration in chylomicrons and VLDL fraction | 48 months |
Secondary
| Measure | Time frame |
|---|---|
| insulin sensitivity | 48 months |
| plasma and adipose tissue adipokines | 48 months |
| endothelial function | 48 months |
Countries
Italy
Outcome results
None listed