Non-thyroidal Illness Syndrome
Conditions
Brief summary
This study is planned to medicate oral T3(Liothyronine)to the patients who are planned to have OPCAB(off- pump coronary bypass graft surgery. The aim of this study was to assess the effects of oral triiodothyronine (T3) therapy on postoperative thyroid hormone concentrations, hemodynamic variables and outcomes in patients undergoing OPCAB in a randomized, controlled trial.
Interventions
liothyronine sodium 20ug, every 12hour (before anesthetic induction, total 4 times)
DRUGplacebo
vitamin B12
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients who are undergoing Off-pump coronary artery bypass graft
Exclusion criteria
* No normal sinus rhythm, * History of thyroid disease * Abnormal thyroid hormone * Renal dysfunction * Hepatic dysfunction * LVEF \<30% * Recent MI * Active infection 1\ 15
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| compare the serum T3 concentrations and the number of patients with serum T3 concentrations below the normal range between the groups | until 36 hours after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| difference of hemodynamic performance and myocardial injury | during surgery and 36 hr after surgery | difference of hemodynamic performance and myocardial injury between the groups |
Other
| Measure | Time frame |
|---|---|
| major morbidity endpoints including acute renal failure, cardiovascular failure, stroke, mediastinitis, need for ventilator support for >48 h, and new onset atrial fibrillation | until discharge of hospital |
Countries
South Korea
Outcome results
None listed