Mechanisms of Stroke in Intracranial Stenosis

Mechanisms of Stroke in Intracranial Stenosis and Stenting

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01152944

Acronym

MoSIS

Enrollment

100

Registered

2010-06-29

Start date

2010-07-31

Completion date

2011-12-31

Last updated

2012-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Keywords

Symptomatic intracranial atherosclerotic disease enrolled in the medical arm of SAMMPRIS

Brief summary

The objective of this SAMMPRIS-affiliated study is to understand the mechanisms the mechanisms that underlie ischemic stroke recurrence in high-grade intracranial atherosclerotic disease in order to determine predictors of recurrent stroke. MoSIS will evaluate 6 specific mechanisms of stroke in the medically-treated SAMMPRIS cohort: decreased antegrade flow, progression of stenosis, decreased proximal collateral flow, decreased distal collateral flow, impaired cerebrovascular reserve, and artery-to-artery embolism.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Enrolled in the medical arm of SAMMPRIS, signed consent

Exclusion criteria

* For QMRA testing: contraindications to MRI; for TCD testing, abscence of ultrasonographic windows.

Design outcomes

Primary

Measure	Time frame
Ischemic stroke in the territory of the stenotic artery	2 years from enrollment

Countries

United States

Outcome results