Cardiovascular Event, Chronic Kidney Disease, End Stage Renal Disease, Sudden Cardiac Death
Conditions
Keywords
end stage renal disease, chronic kidney disease, cardiovascular event, sudden cardiac death, autonomic function
Brief summary
The purpose of this study is to evaluate the use of non-invasive markers of the autonomic function and micro- and macrocirculation to predict mortality and cardiovascular end points in end-stage renal disease patients. Furthermore we aim at getting new insight into the insufficiently understood pathophysiology leading to excessively high cardiovascular and non-cardiovascular mortality in dialysis patients.
Interventions
None listed
Sponsors
Else Kröner Fresenius Foundation
AIT Austrian Institute of Technology GmbH
Ludwig-Maximilians - University of Munich
FH Aachen, University of applied sciences
Technical University of Munich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age 18 or older 2. End-stage renal disease (ESRD) and receiving maintenance hemodialysis
Exclusion criteria
1. Any clinically significant infection. 2. pregnancy 3. history of malignant disease with a prognostic life expectancy less than 24 months 4. missing of written and informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality of all causes | 24 months | 24 month follow up |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of cardiovascular events | 24 months | 24 month follow up |
| Blood pressure drops within a dialysis session | 24 months | 24 month follow up |
| Incidence of infections requiring antibiotic treatment | 24 months | 24 month follow up |
| Incidence of shunt thrombosis | 24 months | 24 month follow up |
| incidence of death and hospitalization due to infection | 24 months | 24 month follow up |
Countries
Germany
Outcome results
None listed