Aortic Surgery and Treatment Post Operative With Paracetamol During 4 Days
Conditions
Keywords
Post operative conditions, paracetamol metabolites
Brief summary
Follow-up of urinary concentration from paracetamol metabolites by patients with aortic surgery during 4 days therapeutic intake (perfalgan ® 4 x 1g IV/day)
Detailed description
D-15 to D0: selection * patient information and non-opposition obtained * inclusion and non inclusion criteria check * clinical exam D-1 to D0 : 24 hours diuresis D0 : operation day Before anesthesia : * urine collection (paracetamol metabolites dosage) * blood sampling (glutathion and liver function test) Surgery: * 1st paracetamol intake before closing * Then administration every 6 hours D1 to D4 : * 24 hours urine collection (metabolites dosage) * blood sampling et D1 and D4(glutathion and liver function test) D5 : final clinical exam
Interventions
None listed
Sponsors
University Hospital, Clermont-Ferrand
Study design
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* aortic surgery * treatment with intraveinous paracetamol (4 grammes daily during 4 days) * patient agrees to participate
Exclusion criteria
* \- patient disagrees * paracetamol contra-indication * paracetamol intake 5 days before surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Follow-up of urinary concentration from paracetamol metabolites by patients with aortic surgery during 4 days therapeutic intake (perfalgan ® 4 x 1g IV/day) | during 4 days therapeutic intake |
Secondary
| Measure | Time frame |
|---|---|
| - Follow-up of glutathion concentration during 4 post operative days | during 4 post operative days |
| Monitoring of liver function | — |
Countries
France
Outcome results
None listed