Experimental Study to Validate the Modified Glucose Disposal Test

Experimental Medicine Study to Validate the Modified Glucose Disposal Test in Healthy Subjects and Subjects With Type 2 Diabetes

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01152372

Enrollment

Registered

2010-06-29

Start date

2010-06-30

Completion date

2010-11-30

Last updated

2011-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes

Brief summary

Evaluate the modified GDT as a measure of key metabolic characteristics in healthy subjects and those with type 2 diabetes mellitus

Interventions

PROCEDUREInsulin, glucose and staple isotopes

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of Type 2 diabetes * Clinically healthy * Drug naive or on a stable dose of metformin monotherapy and/or a secretagogue

Exclusion criteria

* Type 1 Diabetes * History of significant heart disease. * Bariatric surgery * Exposure to fibrates, thiazolidinediones, insulin, exenatide, pramlintide or DPP-IV inhibitors

Design outcomes

Primary

Measure	Time frame
Glucose (labeled and unlabeled), insulin and c-peptide will be measured to calculate insulin sensitivity, endogenous glucose production and insulin secretion	within 24 hours

Secondary

Measure	Time frame
Characterize the patterns of intermediate metabolites in healthy subjects and subjects with type 2 diabetes mellitus	within 24 hours

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026