Rectal Cancer
Conditions
Keywords
quality of life, rectal cancer
Brief summary
The goal of this study is gathering informations about patients' quality of life after combined modality treatment of rectal cancer to evaluate how combined modality treatment for rectal cancer affects patients' quality of life. The findings of this study may provide us important information that can be used in treatment decision and to develop programs to improve quality of life of patients with rectal cancer.
Detailed description
Over the last two decades, rectal cancer research has lead to better understanding of disease behaviour, resulting in more efficient treatments and higher prevalence of cancer survivors.Due to aggressive therapy, rectal cancer survivors can exhibit late sequelae of treatment, most common being impaired bowel, voiding, sexual malfunctioning and quality of life impairment. In order to determine the impact of rectal cancer and its treatment on patients' quality of life over time, this study will prospectively follow a cohort of patients at specified intervals evaluating their physical symptoms, physical and social functioning and overall quality of life.Medical and sociodemographic factors that might be predictive will be tested.
Interventions
BEHAVIORALquestionnaires
Quality of life assessment using questionnaires EORTC QLQ C30 and 38 at baseline, one year and two years after the surgery of rectal cancer, treated with preoperative capecitabine based radiochemotherapy
Sponsors
Institute of Oncology Ljubljana
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* histologically verified adenocarcinoma of the rectum, * clinical stage II or III (IUCC TNM classification 2002); * no prior radiotherapy and/or chemotherapy; * World Health Organisation (WHO) performance status \< 2; * age at diagnosis of 18 or older; * and adequate bone marrow, liver, renal and cardiac function (no history of ischemic heart disease) * mentally fit to complete questionnaires
Exclusion criteria
* a history of prior malignancy other than non-melanoma skin cancer or in situ carcinoma of the cervix rendered the patient ineligible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To prospectively evaluate the quality of life of patients one year after rectal cancer resection | one year after the operation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To prospectively evaluate the quality of life of patients at baseline | before treatment (at baseline) | consecutive patients treated winh capecitabine-based radiochemotherapy |
| To prospectively evaluate the quality of life of patients two years after rectal cancer resection | two years after the operation | — |
Countries
Slovenia
Outcome results
None listed