Metabolic Syndrome, Obesity
Conditions
Keywords
Resveratrol, Diabetes, SIRT1, STAT5, IGF-I, Growth hormone, NAFLD, Longevity, Substrate metabolism, Calorie restriction
Brief summary
We want to investigate whether the food supplement resveratrol is able to counteract the detrimental effects of obesity.
Detailed description
The aim of this study is to investigate potential metabolic effects of resveratrol in healthy but obese men. We hypothesize that resveratrol will counteract some of the detrimental effects of obesity, and as an imitator of calorie restriction will give new insight into the basic biochemical pathways underpinning human metabolism. Of special interest is the potential connection between resveratrol, calorie restriction, SIRT1, STAT5b and the GH/IGF-I axis.
Interventions
DIETARY_SUPPLEMENTResveratrol
500 mg three times a day for five weeks.
OTHERPlacebo
Placebo (starch capsules) 500 mg three times a day for five weeks.
Sponsors
The Ministry of Science, Technology and Innovation, Denmark
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* BMI \> 30 kg/m2 * Otherwise healthy * Written informed consent
Exclusion criteria
* Any disease * Alcohol dependency * Allergy to trial medication * Present or previous malignancy * Participation in other clinical trials within three months before randomization
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic parameters | Five weeks | Regarding glucose, protein and fat metabolism. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pathways of substrate metabolism. | Five weeks | Description of the biochemical pathways underpinning the interplay between calorie restriction, SIRT1, STAT5 and the GH/IGF-I axis. |
Countries
Denmark
Outcome results
None listed