Osteopenic Women
Conditions
Keywords
Osteoporosis, Fracture, Bone microarchitecture
Brief summary
QUALYOR is a prospective study on the predictive value for fragility fracture of various new techniques assessing bone quality, among postmenopausal women with low bone mass.
Interventions
OTHERBone quality complementary exams
realisation of following exams to evaluate fracture risk in osteopenic women: * hip and wrist Dual energy X-ray Absorptiometry (DXA) * wrist and shin High-Resolution peripheral Quantitative Computed-Tomography(HR-pQCT) * hip Quantitative Computed Tomography (QCT) * High Resolution Digital X-Ray of calcaneum using BMA(tm) system * low-dose stereoradiography using EOS(tm) system (only for a sub-group of 60 voluntary subjects)
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 50 or older women * post-menopausal since at least one year * with osteopenia (T-score between -1.0 and -2.5 (with clinical factor risk) or -3.0 (without clinical factor risk)
Exclusion criteria
* corticosteroid therapy \> 3 months, at least 7.5mg/day equivalent prednisolon (stopped since at least 1 year) * osteoporosis treatment antecedent * fragility fracture antecedent * on going post-menopausal hormonal treatment * clinical signs of hepatic, cardiac or respiratory insufficiency, diseases possibly affecting bone metabolism * life expectancy \< 4 years, mental or serious illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fragility fracture | 4 years | Appearance of vertebral or non-vertebral fracture during the 4 years follow-up |
Countries
France
Outcome results
None listed