Role of Cord Blood Hormones and Epinephrine in the Development of Transient Tachypnea of the Newborn

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01149928

Enrollment

Registered

2010-06-24

Start date

2008-09-30

Completion date

2009-10-31

Last updated

2010-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Wet Lung

Keywords

Fetal lung fluid, Pulmonary adaptation, Transient tachypnea of the newborn, Epinephrine, Stress hormones

Brief summary

In this prospective, cross-sectional study, the aim was to investigate the possible role of cord stress hormones; adrenocorticotropic hormone (ACTH), cortisol, epinephrine, sT3, sT4, and thyroid-stimulating hormone (TSH) in the development of Transient Tachypnea of the Newborn (TTN), via their modulatory effect on epithelial sodium channels and Na-K-ATPase.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

34 Weeks to 40 Weeks

Healthy volunteers

Yes

Inclusion criteria

* Gestation age \> 34 weeks * C/S delivered infants * Parental consent form signed

Exclusion criteria

* Gestation age \< 34 weeks * Maternal conditions that compromised fetal well-being (hypertensive disorder, diabetes, chorioamnionitis) * Intrauterine growth retardation * Congenital malformations * Absence of parental consent

Design outcomes

Primary

Measure	Time frame	Description
Stress response at birth, as demonstrated by cord cortisol, adrenocorticotropic hormone, epinephrine, fT3, fT4, and thyroid-stimulating hormone in late preterm and term neonates developing transient tachypnea of the newborn.	postnatal first 24 hours	At birth cord blood samples and perinatal data were collected from ceseraen deliveries of late preterm and term infants. Cord stress hormones of the infants with the diagnosis of TTN and gestational age matched controls were analyzed.

Outcome results