Transcranial Direct Current Stimulation to Treat Major Depressive Disorder

An Open-label, Crossover Study on Major Depressive Disorder Using Transcranial Direct Current Stimulation

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01149889

Enrollment

Registered

2010-06-24

Start date

2010-06-30

Completion date

2011-12-31

Last updated

2011-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder

Brief summary

The investigators purpose is to offer active Transcranial Direct Current Stimulation (tDCS) in patients of the investigators previous study who received either placebo or sertraline and have not responded.

Interventions

PROCEDUREtranscranial direct current stimulation

Transcranial direct current stimulation will be applied at 2mA, 30 minutes/day, for 10 weekdays consecutively

Study design

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

Patients from a previous study (ID:USP-HU-001) who: * received sertraline and did not respond. * received placebo and did not respond.

Exclusion criteria

Patients from a previous study who: * received active tDCS. * responded.

Design outcomes

Primary

Measure	Time frame	Description
Treatment Response	Week 1	Response is defined as MADRS \<=12 or less than 50% of baseline MADRS (Montgomery Asberg depression rating score).
Treatment response	Week 2	Response defined as above.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026