Autoimmune Diabetes
Conditions
Keywords
Autoimmune diabetes, LADA, T-reg, cytokine
Brief summary
Autoimmunity is the main cause of diabetes type 1 and an important factor as cause of Latent Autoimmune Diabetes in Adults (LADA). Recently, research has found that being deficient of T-reg cells is an important cause of autoimmunity. The study hypothesis are: 1. Patients with newly found diabetes type 1 have less T-reg than healthy. 2. Patients with newly found diabetes type 1 have less T-reg than patients with long duration of the illness. 3. The number of T-reg is negative associated with HLA-risk-haplotype. 4. The number of T-reg is negative associated with LADA. 5. Differences relating to inflammatory cytokines will be seen among patients with newly found diabetes type 1, but not among others.
Detailed description
Research has worked out that b-cells are being destroyed by cytokines released from inflammatory cells. One hypothesis in that T-reg is a cause of autoimmunity, and that T-reg concentrations are low in patients with newly diagnosed diabetes type 1. Blood samples will be taken from 10 patients with newly diagnosed type 1 diabetes, Latent Autoimmune Diabetes in Adults (LADA) and type 1 diabetes older than 10 years and the same amount of samples from healthy, age- and sex-matched blood donors. Markers of autoimmune diabetes will be analyzed.
Interventions
None listed
Sponsors
Norwegian University of Science and Technology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* newly diagnosed diabetes type 1 * LADA * diabetes type 1 older than 10 years
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T-reg | — |
Secondary
| Measure | Time frame |
|---|---|
| HLA, anti-GAD, anti-IA2, white blood count, CRP, fasting C-peptide, HbA1c | — |
Outcome results
None listed