Celiac Disease
Conditions
Keywords
Celiac disease, Gluten-free diet, Screen-detected, Asymptomatic, Quality of life, Self-perceived health, Healthcare resource utilization
Brief summary
The main purpose of this study is to assess the impact of the diagnosis of celiac disease on general health, healthcare resource utilization, quality of life and lifestyle. We hypothesize that diagnosis and subsequent dietary treatment may have positive impact on these variables.
Detailed description
All new members with biopsy-proven celiac disease joining the Finnish Celiac Society will be categorized in three groups according to symptoms and signs leading to the diagnosis as classical symptoms, extraintestinal symptoms and screen-detected, the latest being further divided to those presenting with symptoms and those who are totally asymptomatic. Several parameters assessing general health and well-being, quality of life and healthcare resource utilization are evaluated at baseline and after one and five years on trial. Quality of life is compared to that of non-celiac controls.
Interventions
None listed
Sponsors
Tampere University
Finnish Celiac Society
Tampere University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* diagnosis within one year * biopsy-proven diagnosis
Exclusion criteria
* Celiac disease diagnosis previously than within one year * No biopsy-proven diagnosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Psychological General Well-Being (PGWB) Index | 5 years | Health-related quality of life and self-perceived health are evaluated at diagnosis and after five years on dietary treatment by using structured questionnaire |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gastrointestinal Symptoms Rating Scale (GSRS) | 5 years | clinical symptoms are evaluated at diagnosis and after five years on dietary treatment by using structured questionnaire |
| dietary compliance | 5 years | self-assessed compliance to the dietary treatment |
| healthcare resource utilization | 5 years | Healthcare resuorce utilization measured as inpatient and outpatient visits and consumption of other medical services in addition to consumption of pharmaceutical agents |
| height | 5 years | effect of the dietary treatment in the height of children with celiac disease |
| The Short Form (SF-36) Health Survey | 5 years | Health-related quality of life and self-perceived health are evaluated at diagnosis and after five years on dietary treatment by using structured questionnaire |
| weight | 5 years | effect of the dietary treatment in the weight of celiac disease patients |
Countries
Finland
Outcome results
None listed