Aging
Conditions
Keywords
muscle, FSR, protein, meat
Brief summary
Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether meat structure plays an important role in protein digestion, to maximise the amino acid availability and to stimulate the muscle protein growth in elderly people.
Interventions
OTHERIntact or minced beef meat
135 gram piece of intact or minced beef meat, beef steak or minced beef resp.
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
65 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Non-obese male subjects (BMI\<30) between the age of 65-85 years.
Exclusion criteria
* Type II diabetes or other known diseases, use of medication, female, other ages or BMI than indicated above, participation in any regular exercise program.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle protein synthesis | 6 h postprandial period | Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound D5phe tracer, by the enrichment of the precursor (=plasma availability). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dietary amino acid plasma availability | 6h postprandial period | The exogenous rate of phenylalanine appearance will be used to assess the bio-availability of dietary-protein derived amino acids in the circulation during the 6h postprandial period following meat intake |
Countries
Netherlands
Outcome results
None listed