Cephalic Phase Insulin Secretion and Capillary Recruitment in Healthy Men

Relations Among Cephalic Phase of Insulin Secretion, Body Composition, Dietary Intake and Microvascular Reactivity in Healthy Young Men

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01145027

Enrollment

Registered

2010-06-16

Start date

2009-06-30

Completion date

2010-08-31

Last updated

2010-10-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Microvascular Function

Keywords

Capillary recruitment, Cephalic Phase of Insulin Secretion, Dietary Intake

Brief summary

Forty healthy volunteers will undergo two nailfold-videocapillaroscopy exams with a 10-minute interval between them, after an 10-h overnight fast in a temperature controlled room. The subjects will be randomized in two groups: one will receive a sensorial stimulus during the interval (stimulus group - SG) and the other will receive no stimulus (control group - CG). The sensorial stimulus will be a breakfast meal, with excellent presentation and aroma, composed by favorite food items previously related by the individual for this meal. The meal will not be offered for immediate intake, it will be placed in front of the volunteer for perception of the smell and taste. Baseline microvascular parameters will be compared to the results after the interval. The investigators hypothesize that the SG will have greater capillary recruitment due to a possible effect of physiologically secreted insulin provoked by the sensorial stimulation (cephalic phase of insulin secretion).

Interventions

OTHERBreakfast tray

The sensorial stimulus will be a breakfast meal, with excellent presentation and aroma, composed by favorite food items previously related by the individual for this meal. The meal will not be offered for immediate intake, it will be placed in front of the volunteer for perception of the smell and taste.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy male volunteers * Aged between 18 and 30 years * BMI between 18.5 and 24.9 kg/m2

Exclusion criteria

* Diabetes mellitus, glucose intolerance or altered fasting glucose; * Hypertension (Systolic pressure ≥ 130 mmHg and diastolic pressure ≥ 80 mmHg); * HOMA-index ≥ 2.71 * Dyslipidemia * Renal disease, coronary or peripheral vascular diseases, haematologic or hepatic diseases * Smoking * Chronic use of any medication

Design outcomes

Primary

Measure	Time frame
functional capillary density (number of perfused capillaries on the studied skin area)	up to 30 minutes

Secondary

Measure	Time frame
cephalic phase of insulin secretion (the occurence of increase in markers of this phase, such as insulin, C-peptide and pancreatic polypeptide)	Up to 30 minutes

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026