Aortic Stenosis, Cardiopulmonary Bypass, Hypertrophy, Left Ventricular, Myocardial Ischemia
Conditions
Brief summary
Purpose: The effect of intravenous glutamate infusion on myocardial diastolic function and overall hemodynamics were studied in patients undergoing elective aortic valve replacement with severe aortic stenosis and associated left ventricular hypertrophy . Methods: 25 patients will be included in this double-blind randomized placebo-controlled study. Glutamate was administered intravenously immediately after aortic cross-clamp release. The patients receive either a low dose of 30mg kg-1 h-1 (LG-group) or high dose of 60 mg kg-1 h-1 (HG-group) or placebo (P-group) at a rate of 3.3ml kg-1h-1 for 2h. Transesophageal echocardiography (TEE) is used to measure diastolic and systolic ventricular function before sternotomy (T0), and 2h (T2), 3h (T3) and 6h (T4) after release of cross clamp. Additionally routine hemodynamic parameters are measured intraoperatively.
Interventions
DRUGLG-group
DRUGHG-group
DRUGPlacebo-group
Sponsors
Medical University of Vienna
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Eligibility
Sex/Gender
ALL
Age
19 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* severe aortic stenosis * left ventricular hypertrophy of more than 10mm IVS thickness * normal ejection fraction * SR
Exclusion criteria
* moderately or severely reduced systolic left ventricular function (ejection fraction \<30%) * atrial fibrillation or flutter * intolerance to glutamate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| E/A ratio | — |
| Isovolumic relaxation time | — |
| E-velocity | — |
| A-velocity | — |
| flow propagational velocity | — |
Secondary
| Measure | Time frame |
|---|---|
| cardiac output | — |
| mitral ring motion | — |
| ejection fraction | — |
Countries
Austria
Outcome results
None listed