Dose Response Effect of Probiotics for the Prevention of Antibiotic-associated Diarrhea in Chinese Adults

Dose Response Effect of a Proprietary Probiotic Formula for the Prevention of Antibiotic-associated Diarrhea in Chinese Adults

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01143623

Enrollment

510

Registered

2010-06-14

Start date

2010-05-31

Completion date

2011-07-31

Last updated

2011-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antibiotic-associated Diarrhea

Keywords

antibiotic, diarrhea, probiotic

Brief summary

The purpose of this study is to determine the dose response effect of probiotic capsules for the prevention of antibiotic-associated diarrhea (AAD).

Interventions

OTHERPlacebo

Placebo

DIETARY_SUPPLEMENTProbiotic

L. acidophilus, L. paracasei, B. lactis; 2.5 billion cfu capsule once per day

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

30 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* age 30-70 years * initiating antibiotic therapy * informed consent

Exclusion criteria

* current diarrhea * life threatening illness * habitual probiotic use

Design outcomes

Primary

Measure	Time frame
Incidence of antibiotic-associated diarrhea	5 weeks after antibiotic discontinuation

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026